testolactone

testolactone

(tĕs-tō-lăk′tōn)
An antineoplastic agent used in treating carcinoma of the breast in postmenopausal women.
References in periodicals archive ?
Treatment with drugs that interfere with the metabolism of testosterone, such as anastrozole, clomiphene, dutasteride, finasteride, flutamide, ketoconazole, spironolactone, or testolactone;
They are classified chemically into steroidal and nonsteroidal groups, but currently available aromatase inhibitors include testolactone, anastrozole, and letrozole.
Reversal of the hypogonadotropic hypogonadism of obese men by administration of the aromatase inhibitor testolactone. Metabolism 2003 Sep;52(9):1126-1128.
After one year of treatment, initially with testolactone, followed by anastrozole, the breast diameter of the patient decreased from 7 cm to 3 cm, and, in parallel, testicular volume receded from 5 mL to < 4 mL.
Sertoli cell tumor causing prepubertal gynecomastia in a boy with Peutz-Jeghers syndrome: the outcome of 1-year treatment with the aromatase inhibitor testolactone. Horm Res 2005;63:252-256.
Aromatase inhibitors, including but not limited to: aminoglutethimide, anastrozole, exemestane, formestane, letrozole, testolactone
(8.) Waddell WR, Kirsch WM: Testolactone, sulindac, warfarin and vitamin K1 for unresectable desmoid tumors.
Aromatase inhibitors such as testolactone, anastrozole, and letrozole can decrease the synthesis of estrogen by inhibiting aromatization of androgens.
Agents with anti-estrogenic activity: Aromatase inhibitors including anastrozole, letrozole, aminoglutethimide, exemestane, formestane, testolactone; selective estrogen receptor modulators including raloxifene, tamoxifen, toremifene
(16) Antiestrogen drugs such as tamoxifen and testolactone have been used in selected cases with success.
Treatment of precocious puberty in the McCune-Albright syndrome with the aromatase inhibitor testolactone. N Engl J Med 1986;315:1115-9.