testicular feminization syndrome


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Related to testicular feminization syndrome: Kallmann syndrome

testicular

 [tes-tik´u-lar]
pertaining to the testis.
testicular feminization syndrome complete androgen resistance.

tes·tic·u·lar fem·i·ni·za·tion syn·drome

[MIM*313700]
a type of male pseudohermaphroditism characterized by female external genitalia (may be ambiguous if the syndrome is incomplete), incompletely developed vagina often with rudimentary uterus and fallopian tubes, female habitus at puberty with normal size breasts but with scanty or absent axillary and pubic hair and amenorrhea, and testes present within the abdomen or in the inguinal canals or labia majora; epididymis and vas deferens are usually present; androgens and estrogens are formed, but target tissues are largely unresponsive to androgens; individuals have a normal male karyotype; X-linked recessive inheritance, caused by mutation in the androgen receptor gene (AR) on chromosome Xq.
See also: complete androgen insensitivity syndrome.

tes·tic·u·lar fem·i·ni·za·tion syn·drome

[MIM*313700]
a type of male pseudohermaphroditism characterized by female external genitalia (may be ambiguous if the syndrome is incomplete), incompletely developed vagina often with rudimentary uterus and fallopian tubes, female habitus at puberty with normal size breasts but with scanty or absent axillary and pubic hair and amenorrhea, and testes present within the abdomen or in the inguinal canals or labia majora; epididymis and vas deferens are usually present; androgens and estrogens are formed, but target tissues are largely unresponsive to androgens; individuals have a normal male karyotype; X-linked recessive inheritance, caused by mutation in the androgen receptor gene (AR) on chromosome Xq.
See also: complete androgen insensitivity syndrome.

tes·tic·u·lar fem·i·ni·za·tion syn·drome

(tes-tik'yū-lăr fem'i-nī-zā'shŭn sin'drōm)
A type of male pseudohermaphroditism characterized by female external genitalia, incompletely developed vagina (often with rudimentary uterus and uterine tubes), female habitus at puberty but with scanty or absent axillary and pubic hair and amenorrhea, and testes present within the abdomen or in the inguinal canalsor labia majora; epididymis and vas deferens are usually present; androgens and estrogens are formed, but target tissues are largely unresponsive to androgens; affected people are sex chromatin-negative and have a normal male karyotype; there is a defect in the androgen receptor protein.
Synonym(s): complete androgen insensitivity syndrome.

testicular feminization syndrome

A rare X-linked, genetically induced defect of the male sex hormone receptors on the surface of body cells in men. Male hormones are thus unable to act and normal male characteristics cannot develop. There is male PSEUDOHERMAPHRODITISM. The testicles are present, but undescended, the penis is rudimentary and there is a short, blind-ended vagina. The breasts may be well developed. It is usual to removed the testicles and give female sex hormones to promote full development of the nominal female sex.

testicular

pertaining to the testis.

testicular agenesis
absence of one or both testes, usually part of a wider range of defects.
testicular anomaly
includes hypoplasia, cryptorchidism, agenesis, heterotopia, polyorchidism, cystic rete testis and heterotopic Leydig cells and accessory adrenal cortical tissue.
testicular biopsy
percutaneous sampling of tissue for laboratory examination; disruption of normal spermatogenesis can be expected.
testicular calcinosis
common as a sequel to chronic inflammation and concurrent with fibrosis.
testicular degeneration
the most frequent cause of male infertility; many causes; regeneration and return to normal function possible provided some spermatogonia survive the insult and the basement membrane of the tubules is undamaged.
testicular descent
includes a long-distance, passive descent from the roof of the abdomen to near the inguinal canal followed by a short-distance, also passive, descent through the inguinal canal into the scrotum.
testicular feminization syndrome
an extreme form of male pseudohermaphroditism, with female external development, including secondary sex characteristics, but with the presence of testes and absence of uterus and tubes; it is due to end-organ resistance to the action of testosterone.
testicular fibrosis
a sequel to inflammation or degeneration; common in old bulls.
testicular foreign body constriction
malicious application of a constricting foreign body, usually an elastic band, around the base of the scrotum in dogs is an occasional cause of orchitis and often necessitates castration with scrotal ablation. Called also the 'nasty child syndrome', although 'bull terrier bite' would probably be more common.
testicular hypoplasia
occurs as an uncomplicated state, or as part of cryptorchidism or intersex anomaly; an inherited defect in Swedish Highland cattle.
testicular inflammation
testicular lobuli
lobules created in the testis by connective tissue septa.
testicular mediastinum
the central dividing plane of tissue which divides the testis and is continuous with its tunica albuginea.
testicular septuli
loose connective tissue septa which divide testis into lobules.
testicular torsion
causes pain and swelling of the scrotum, abdominal pain and vomiting. In dogs, testicles with neoplasms are predisposed to torsion. Occurs occasionally in stallions (180° torsion), with no apparent detrimental consequences on health or fertility.
testicular tumors
includes interstitial cell and Sertoli cell tumors and seminomas.