testicular failure

testicular failure

Endocrinology The inability of the testes to produce sperm or hormones Etiology Chromosome defects, testicular torsion, direct trauma, mumps orchitis, testicular CA, various drugs Risk factors Cryptorchidism, constant low-level scrotal trauma–eg, motorcycle use, frequent use of drugs affecting testicular function–eg, marijuana, some prescription drugs. See Cryptorchidism.
References in periodicals archive ?
Donor sperms- There are also cases of complete testicular failure with abnormal hormones and no sperms.
In males, hypogonadism is commonly seen and may have primary testicular failure.
Serum FSH elevations are indicative of disturbances in spermatogenesis such as primary testicular failure (hypergonadotropic hypogonadism), although normal FSH levels do not dismiss spermatogenic failure.
22) With the exclusion of cases of high LH or FSH denoting primary testicular failure from our study, we found that the duration of infertility and preoperative LH and FSH levels did not affect the impact of the varicocelectomy on postoperative semen analysis.
Patients with Klinefelter syndrome tend to have a pattern of primary testicular failure, such as low to low-normal testosterone and elevated luteinizing hormone (LH), follicular stimulating hormone (FSH), and serum estradiol.
Serum hormone levels testosterone, LH and FSH were advised to determine whether the patient had gonadotropin deficiency (low testosterone and low or inappropriately normal LH and FSH), primary testicular failure (low testosterone, elevated LH and FSH), selective spermatogenic failure (normal testosterone and LH, elevated FSH), or androgen resistance (high testosterone, elevated LH).
The distinction is important because combined and secondary defects might be caused by specific diseases that may require treatment; and the potential to restore fertility in some patients with secondary testicular failure with correct hormone stimulation.
For men with a zero sperm count (azoospermia), testicular biopsy is done to determine if a blockage is present or if primary testicular failure is the cause.
Most male factor infertilities are due to testicular failure which results in a decline in semen quality (3).
Gonadotropin levels can help delineate whether hypogonadism is caused by primary testicular failure (hypergonadotropic hypogonadism) or by pituitary disease (hypogonadotropic hypogonadism).
She and her colleagues recently uncovered deficiencies in mismatch repair genes in some men with testicular failure, predominantly those with Sertoli-cell-only syndrome (Mol.
Hypogonadal function occurs as a result of testicular failure either primary or secondary to altered hypothalamic-pituitary-gonadal function.