testicular failure

testicular failure

Endocrinology The inability of the testes to produce sperm or hormones Etiology Chromosome defects, testicular torsion, direct trauma, mumps orchitis, testicular CA, various drugs Risk factors Cryptorchidism, constant low-level scrotal trauma–eg, motorcycle use, frequent use of drugs affecting testicular function–eg, marijuana, some prescription drugs. See Cryptorchidism.
References in periodicals archive ?
22) With the exclusion of cases of high LH or FSH denoting primary testicular failure from our study, we found that the duration of infertility and preoperative LH and FSH levels did not affect the impact of the varicocelectomy on postoperative semen analysis.
450 IU vial is indicated for the induction of spermatogenesis in men with primary and secondary hypogonadotropic hypogonadism in whom the cause of infertility is not due to primary testicular failure as well as for ovulation induction and the development of multiple follicles in the ovulatory female patient participating in an Assisted Reproductive Technology (ART).
The distinction is important because combined and secondary defects might be caused by specific diseases that may require treatment; and the potential to restore fertility in some patients with secondary testicular failure with correct hormone stimulation.
For men with a zero sperm count (azoospermia), testicular biopsy is done to determine if a blockage is present or if primary testicular failure is the cause.
Most male factor infertilities are due to testicular failure which results in a decline in semen quality (3).
She and her colleagues recently uncovered deficiencies in mismatch repair genes in some men with testicular failure, predominantly those with Sertoli-cell-only syndrome (Mol.
Hypogonadal function occurs as a result of testicular failure either primary or secondary to altered hypothalamic-pituitary-gonadal function.
FSH, the active ingredient in Gonal-F(R), induces ovulation in women and production of sperm in men, provided that the cause of their infertility is not due to primary testicular failure.
In addition, it is appropriate for men with certain reproductive abnormalities, including obstructed or absent vas deferens and testicular failure with no sperm in the ejaculate.
It was illuminating that in this clinical trial less than 5% of the 600 patients screened were characterized as having primary testicular failure as determined by elevated LH, the pituitary hormone responsible for driving the testicular production of testosterone.
2) Testicular failure or non-obstructive azoospermia (49%-93% of men with azoospermia); or a) While the term testicular failure would seem to indicate a complete absence of spermatogenesis, men with testicular failure actually have either reduced spermatogenesis, maturation arrest or a complete failure of spermatogenesis noted with Sertoli-cell only syndrome.
In the US, GONAL-f(R) Multi-Dose, available as the GONAL-f(R) 1050 IU vial or GONAL-f(R) 450 IU vial is indicated for the induction of spermatogenesis in men with primary and secondary hypogonadotropic hypogonadism in whom the cause of infertility is not due to primary testicular failure as well as for ovulation induction and the development of multiple follicles in the ovulatory female patient participating in an Assisted Reproductive Technology (ART).