testicular dysgenesis

tes·tic·u·lar dys·gen·e·sis

[MIM*305700]
a congenital derangement of seminiferous tubular structure and function, resulting in male infertility; the defect in spermatogenesis may be incomplete, as in maturational arrest or premature sloughing, or spermatogenesis may be completely absent, as in the Sertoli-cell-only syndrome.
References in periodicals archive ?
According to the testicular dysgenesis syndrome (TDS) hypothesis, TGCT, cryptorchidism, hypospadias, and reduced sperm count originate from a common fetal disorder hampering the normal male testicular development (Skakkebaek et al.
There is some evidence that epididymal cysts may be part of the testicular dysgenesis syndrome, whereby endocrine disruptors can influence the development of the male genitalia in the embryo.
Third, RSS itself is a risk factor for testicular dysgenesis syndrome (TDS), based on the hypothesis that environmental factors and genetic aberrations or polymorphisms decrease Leydig and Sertoli cell functions.
Fetal testicular dysgenesis syndrome ("phthalate syndrome" in rodents) involves disorders of male genital tract in terms of shortened anogenital distance, hypospadia, cryptorchidism, malformations of the seminal vesicles, prostate, and epididymis [18, 20].
Association between testicular dysgenesis syndrome (TDS) and testicular neoplasia: evidence from 20 adult patients with signs of maldevelopment of the testis.
Thus, our data do not support the hypothesis of shared inheritability of the disorders described under testicular dysgenesis syndrome.
According to the report, genital malformations in boys (collectively known as testicular dysgenesis syndrome or TDS) have their origin during development in the womb, where testosterone is needed to form the male genital organs.
These effects potentially contribute to testicular dysgenesis syndrome.
The testicular dysgenesis syndrome (TDS) hypothesis posits an interrelationship among these adverse outcomes, as manifestations of altered prenatal testicular development in humans (Aschim et al.
A link between this phenomenon and the increase in human male fertility problems caused by testicular dysgenesis syndrome has also been suggested by several other studies.
1-4] Depending on the severity of testicular dysgenesis, the antimullerian hormone (AMH) level may be low or undetectable in patients with abnormal testicular determination.

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