There is some evidence that epididymal cysts, especially those in conjunction with undescended testes may play a role in testicular dysgenesis
syndrome in which male genitourinary anatomy and function are disrupted, however the long-term effects of this are currently unknown (30).
Is a CIS phenotype apparent in children with disorders of sex development?: milder testicular dysgenesis
is associated with a higher risk of malignancy.
According to the testicular dysgenesis
syndrome (TDS) hypothesis, TGCT, cryptorchidism, hypospadias, and reduced sperm count originate from a common fetal disorder hampering the normal male testicular development (Skakkebaek et al.
Maciel-Guerra, "46,XY and 45,X/46,XY testicular dysgenesis
: similar gonadal and genital phenotype, different prognosis," Arquivos Brasileiros de Endocrinologia e Metabologia, vol.
Third, RSS itself is a risk factor for testicular dysgenesis
syndrome (TDS), based on the hypothesis that environmental factors and genetic aberrations or polymorphisms decrease Leydig and Sertoli cell functions.
One hypothesis, the common cause hypothesis (testicular dysgenesis
syndrome), suggests that an unidentified etiology may be a common risk factor for both the development of UDT and abnormal cell development (Ferguson & Agoulnik, 2013).
The impaired quality of sperm production is probably associated with disturbed differentiation of the testicle during the embryonic development of the gonad according to Testicular Dysgenesis
Syndrome (TDS) hypothesis .
According to the report, genital malformations in boys (collectively known as testicular dysgenesis
syndrome or TDS) have their origin during development in the womb, where testosterone is needed to form the male genital organs.
2007 "Relationship between phthalates and testicular dysgenesis
syndrome," National Journal of Andrology 13(3): 195-200.
There is some evidence that epididymal cysts may be part of the testicular dysgenesis
syndrome, whereby endocrine disruptors can influence the development of the male genitalia in the embryo.
The testicular dysgenesis
syndrome (TDS) hypothesis posits an interrelationship among these adverse outcomes, as manifestations of altered prenatal testicular development in humans (Aschim et al.
Partial gonadal dysgenesis (PGD), one of the 46,XY disorders of sex development (DSD) , is a rare disorder characterized by sex ambiguity due to variable degrees of testicular dysgenesis
in individuals without a syndromic picture who have a normal male karyotype.