According to the testicular dysgenesis
syndrome (TDS) hypothesis, TGCT, cryptorchidism, hypospadias, and reduced sperm count originate from a common fetal disorder hampering the normal male testicular development (Skakkebaek et al.
There is some evidence that epididymal cysts may be part of the testicular dysgenesis
syndrome, whereby endocrine disruptors can influence the development of the male genitalia in the embryo.
Third, RSS itself is a risk factor for testicular dysgenesis
syndrome (TDS), based on the hypothesis that environmental factors and genetic aberrations or polymorphisms decrease Leydig and Sertoli cell functions.
Fetal testicular dysgenesis
syndrome ("phthalate syndrome" in rodents) involves disorders of male genital tract in terms of shortened anogenital distance, hypospadia, cryptorchidism, malformations of the seminal vesicles, prostate, and epididymis [18, 20].
Association between testicular dysgenesis
syndrome (TDS) and testicular neoplasia: evidence from 20 adult patients with signs of maldevelopment of the testis.
Thus, our data do not support the hypothesis of shared inheritability of the disorders described under testicular dysgenesis
According to the report, genital malformations in boys (collectively known as testicular dysgenesis
syndrome or TDS) have their origin during development in the womb, where testosterone is needed to form the male genital organs.
These effects potentially contribute to testicular dysgenesis
The testicular dysgenesis
syndrome (TDS) hypothesis posits an interrelationship among these adverse outcomes, as manifestations of altered prenatal testicular development in humans (Aschim et al.
Environment, testicular dysgenesis
and carcinoma in situ testis.
A link between this phenomenon and the increase in human male fertility problems caused by testicular dysgenesis
syndrome has also been suggested by several other studies.
1-4] Depending on the severity of testicular dysgenesis
, the antimullerian hormone (AMH) level may be low or undetectable in patients with abnormal testicular determination.