The test dose
for purposes of our discussion here is a high dose administered in toxicological experiments that is used to predict responses at much lower doses.
Although it is not required by the manufacturer, a test dose
of iron sucrose was administered (0.5 ml over 2 minutes) before giving the repletion dose at the physician's discretion or if the patient had a previous reaction to an iron supplement.
A locked-cap adapter was attached to the distal end of the epidural catheter but it was then observed that it was impossible to inject the test dose
via the catheter.
Ferris gluconate, marketed as Ferrlecit, is associated with an extremely low rate of allergic reactions and no deaths when given intravenously (125 mg over an hour) after a test dose
Before initiating a repletion dose, a one-time IV test dose
of 2 ml sodium ferric gluconate complex (25 mg elemental iron) in saline should be given over 1 hour.
On the first day of treatment, 1ml of drug in 5% Dextrose (500ml) water was given slowly at test dose
. Next, increment dose intermediate between full dose as 0.75 mg/kg body weight, infused in the same manner.
After a test dose
, atracurium (total 30 mg) was given and manual ventilation performed without difficulty for three minutes.
His complex medical history includes multiple drug allergies, latex allergy, and reaction to a test dose
of iron dextran.
Informed consent was obtained from the patients who were then given a preformed questionnaire (Table 1) prior to the procedure and evaluated for awareness of knowledge of local anaesthetic test dose
and its complications.
As soon as the patient was in the supine position, a test dose
of 3 ml 0.5% levobupivacaine (Chirocaine[R], Abbott, Belgium) was injected to exclude subarachnoid positioning of the catheter as proposed by Murdoch et al (16) and Daoud et al (17).
According to our protocol, a 25 mg test dose
diluted in 100 ml normal saline was administered over 30 minutes.