In case of calcification of the pulp, there is an obliteration of the dentinal tubules and accumulation of reactionary tertiary dentin. 1
2007, we observe a yellow discoloration in case of accumulation of tertiary dentin in the canal and the pulp chamber.
Park, "Tertiary dentin
formation after direct pulp capping with odontogenic ameloblast-associated protein in rat teeth," Journal of Endodontics, vol.
In this issue, some researches related to MTA or Biodentine were accepted which have capability to stimulate tertiary dentin
After deep cavity preparations to remove the soft demineralized or infected dentin, the pulp must be indirectly capped using materials that can stimulate biological process that lead to the deposition of tertiary dentin and pulp healing (Tziafas, Koliniotou-Koumpia, Tziafa, & Papadimitriou, 2007).
The dentin-pulp complex is capable of repair after tooth injury, such as caries, attrition, abrasion, and dental procedures, including cavity preparation, resulting in tertiary dentin formation.
(5) Hence, Biodentine is biocompatible it does not damage pulpal cells, and is capable of stimulating tertiary dentin
Further observations on tertiary dentin
in human primary teeth.
It stimulates tertiary dentin
formation on contact with vital pulp cells.2,7 It is composed of powder and liquid, where powder contains mainly tricalcium silicate, zirconium dioxide as radiopacifier, calcium carbonate as filler, dicalcium silicate (traces), calcium oxide (traces) and iron oxide (traces).
In the long term, this acts at the cellular level, increasing the cellular respiration with production of energy (ATP), thus increasing the production of tertiary dentin
and consequently sealing the dentinal tubules.
Studies have demonstrated that prefabricated PLGA/CaP cement loaded with 400 ng of TGF-[beta]1 can trigger resident stem cells in the pulp to differentiate into odontoblast-like cells and induce the formation of tertiary dentin
. (4) The cellular mechanism of the dissolution/precipitation process involved a formation of carbonate hydroxyapatite (CHA) on CaP surfaces in vivo.