After deep cavity preparations to remove the soft demineralized or infected dentin, the pulp must be indirectly capped using materials that can stimulate biological process that lead to the deposition of tertiary dentin and pulp healing (Tziafas, Koliniotou-Koumpia, Tziafa, & Papadimitriou, 2007).
The dentin-pulp complex is capable of repair after tooth injury, such as caries, attrition, abrasion, and dental procedures, including cavity preparation, resulting in tertiary dentin formation.
5) Hence, Biodentine is biocompatible it does not damage pulpal cells, and is capable of stimulating tertiary dentin
Further observations on tertiary dentin
in human primary teeth.
These include sclerosis of dentin, deposition of secondary, and tertiary dentin, creation of a smear layer, and calculus formation on the surface of the dentin.
Tertiary dentin, also known as reparative dentin, forms after exposed dentin has been traumatized by a stimulus.
It stimulates tertiary dentin
formation on contact with vital pulp cells.
In the long term, this acts at the cellular level, increasing the cellular respiration with production of energy (ATP), thus increasing the production of tertiary dentin
and consequently sealing the dentinal tubules.
Studies have demonstrated that prefabricated PLGA/CaP cement loaded with 400 ng of TGF-[beta]1 can trigger resident stem cells in the pulp to differentiate into odontoblast-like cells and induce the formation of tertiary dentin.
Tertiary dentin, tunnels, fibrous formation and plasma cells were observed adjacent to the exposed site (Figure 1).
2] is limited, especially due to the superficial necrosis and the structure quality of the tertiary dentin.