We find that exons with shorter length, weaker splice sites, lower GC content, and more termination codons
are more likely to be skipped during the splicing process.
About half of the 13 protein-coding genes had incomplete termination codons
, whereas the others had the typical TAA stop codon.
Identification of a novel termination codon
mutation (TAA [right arrow] TAT, Term [right arrow] Tyr) in the [[alpha].sub.2] globin gene of a Laotian girl with hemoglobin H disease.
The (+1 G [right arrow] C) substitution of apo CII-Hamburg gives rise to abnormally spliced apo CII messenger RNA, which contains a termination codon
next to the site of the mutation.
Translation initiation and translation termination codons
were identified using genetic codon table for mitochondrion in MEGA 4.0.
Loci and nature of the mutations in MMADHC determine the subtype of cblD disease. Mutation c.24-25delAG at the 5' end of the MMADHC coding sequence is a frameshift mutation that can produce premature termination codons
. On the basis of classical theory, this kind of mutation may lead to a complete the loss of gene function.
These were obtained by calculating the number of GC nucleotides and number of G or C nucleotides at the third position of synonymous codon (G[C.sub.3]), except the start and termination codons
. In addition, the expected effective number of codons (ENC) for each albumin superfamily protein was calculated.
Some SNP's cause amino acid substitutions, while others introduce chain termination codons
, rendering the allele non-functional.
Rather it takes the form of translation termination codons
, most notably, premature translation termination codons
, but it still means nothing and so in the RNA world, can be dangerous.
For example, in kinetoplastid protozoa, RNA editing by addition and deletion of literally hundreds of uridine residues creates initiation and termination codons
, alters the structural features of transcripts, and creates over 90% of the amino-acid codons (5).
Interestingly, 9 of the remaining 12 examples (argCBH, argE P2, crp, dapD, Tn10xxx P3, pBR322 P4, phage T7A3, phage [phi]X174D, and phage [lambda] [P.sub.R]) promote the synthesis of mRNAs in which the leaderless AUG triplets are in-frame with termination codons
anywhere from 2 to 9 codons downstream.