terminal duct lobular unit

terminal duct lobular unit

,

TDLU

The blind ending of the lactiferous duct that contains the lobule and its duct. Most benign and malignant breast lesions arise here.
References in periodicals archive ?
Round & punctate calcifications are 0.5-1mm in size and frequently form in the acini of the terminal duct lobular unit. When calcifications are smaller than 0.5mm term punctate is used.
Terminal duct lobular unit was seen in 26% (17 of 65) of cases.
Terminal duct lobular units are scarce in the nipple: implications for prophylactic nipple-sparing mastectomy: terminal duct lobular units in the nipple.
The descriptive term clear cell change applies to an alteration of the epithelium of the terminal duct lobular unit characterized by cytoplasmic clearing.
Adjacent tissue showed mainly mature adipocytes admixed with few terminal duct lobular units. These histological features are consistent with a fibroadenoma arising from accessory breast tissue.
Prevalence of terminal duct lobular units and frequency of neoplastic involvement of the nipple in mastectomy.
The National Comprehensive Cancer Network (73) (NCCN, Fort Washington, Pennsylvania) states it is reasonable to perform surgical excision of LCIS found in a core biopsy to exclude associated invasive carcinoma or DCIS, but it also adds that classic LCIS involving fewer than 4 terminal duct lobular units in a core biopsy sample for calcifications may be managed by imaging follow-up.
(14) This cell population was able to regenerate itself, myoepithelial cells, and to form terminal duct lobular units. These studies provide evidence of the presence of mammary stem cells, which have the ability to self-regenerate and differentiate into breast parenchyma.

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