5-1mm in size and frequently form in the acini of the terminal duct lobular unit
Terminal duct lobular unit was seen in 26% (17 of 65) of cases.
One of the breast carcinogenesis hypotheses states that, other than intraductal papilloma, all other neoplastic epithelial proliferations, including in situ and invasive carcinoma, develop from terminal duct lobular unit epithelium.
A, A lactiferous duct with surrounding terminal duct lobular unit involved by lobular carcinoma in situ.
9) Literature related to histologic evaluation of terminal duct lobular units (TDLUs) in the entire nipple is limited.
Terminal duct lobular units are scarce in the nipple: implications for prophylactic nipple-sparing mastectomy: terminal duct lobular units in the nipple.
The descriptive term clear cell change applies to an alteration of the epithelium of the terminal duct lobular unit
characterized by cytoplasmic clearing.
The National Comprehensive Cancer Network (73) (NCCN, Fort Washington, Pennsylvania) states it is reasonable to perform surgical excision of LCIS found in a core biopsy to exclude associated invasive carcinoma or DCIS, but it also adds that classic LCIS involving fewer than 4 terminal duct lobular units
in a core biopsy sample for calcifications may be managed by imaging follow-up.
The functional terminal duct lobular units can be generated after transplanting isolated epithelial cells from different regions of mammary glands into the cleared mammary fat pads of mice, which has led to the development of the mammary stem cell hypothesis.
14) This cell population was able to regenerate itself, myoepithelial cells, and to form terminal duct lobular units.