terminal deoxynucleotidyl transferase


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terminal deoxynucleotidyl transferase (TdT),

a specialized DNA polymerase expressed in immature, pre-B, pre-T lymphoid cells, and acute lymphoblastic leukemia/lymphoma cells.

ter·mi·nal de·ox·y·nu·cle·o·ti·dyl trans·fer·ase

(TdT) (tĕr'mi-năl dē-oks'ē-nū-klē-ō-tī'dil trans'fĕr-ās)
A specialized DNA polymerase expressed in immature, pre-B, pre-T lymphoid cells, and acute lymphoblastic leukemia/lymphoma cells.
References in periodicals archive ?
5 TdT TdT CD14 CD24 CD7 CD15 CD1a CD64 Abbreviations: cy, cytoplasmic; IgM, immunoglobulin M; MPO, myeloperoxidase; sm, surface membrane;TCR, T-cell receptor;TdT, terminal deoxynucleotidyl transferase.
Keywords: Behcet disease, neuro-Behcet disease, immunoglobulin G, terminal deoxynucleotidyl transferase dUTP nick end labeling, neurotoxicity
b) The number of terminal deoxynucleotidyl transferase dUTP nick end labeling- (TUNEL-) positive (%) cells was calculated by dividing the number of TUNEL-stained cells by the total number of cells after a 24 h BSO treatment.
Abbreviations: DHTS, dihydrotanshinone I; ROS, reactive oxygen species; DAPI, 4', 6-diamidino-2-phenylindole; TUNEL, terminal deoxynucleotidyl transferase dUTP Nick-end Labeling; O.
Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays.
Briefly, this includes immersion in equilibration buffer for 10 min, application of terminal deoxynucleotidyl transferase (TdT) and dUTP-digoxigenin at 37[degrees]C for 1 hour, followed by stop/wash buffer at 37[degrees]C for 30 minutes incubation with antidigoxigenin for 30 minutes, and visualization with 0.
29 November 2011 - US biopharmaceutical firm OncoVista Innovative Therapies Inc (OTCBB:OVIT) said on Monday it had mandated consulting and clinical research organisation Oncology Therapeutic Development (OTD) to launch a Phase Ib clinical study of Cordycepin related to Pentostatin to treat terminal deoxynucleotidyl transferase (TdT)-positive refractory leukemia.
Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay: TUNEL assay was performed using the DeadEnd Fluorometric TUNEL System kit as instructed by the manufacturer (Promega, Madison, WI, USA).
Terminal deoxynucleotidyl transferase mediated deoxyuridine Triphosphate-Nick End Labeling (TUNEL) assay quantifies the integration of the flurochrome or biotin labeled dUTP at single and double-strand DNA breakages in a reaction catalyzed by the Terminal deoxynucleotidyl Transferase (TdT) enzyme that is not dependent on the template.
Integration of indirect immune-fluorescence and immunoperoxidase staining with morphologic assessment and the terminal deoxynucleotidyl transferase (TdT) positive cells found in normal bone marrow were identified as hematogones3.
Determination of apoptosis by Terminal deoxynucleotidyl transferase (TdT)-mediated dUDP-biotin nick end labeling (TUNEL) assay (Wei et al.
Immunohistochemistry done on the gum biopsy showed the neoplastic cells strongly expressing leukocyte common antigen (LCA), CD3 (Figure 3C), terminal deoxynucleotidyl transferase (TdT) (Figure 3D), and CD5.

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