Moschcowitz, "An acute febrile pleiochromic anemia with hyaline thrombosis of the terminal arterioles
and capillaries," Archives of Internal Medicine, vol.
Seven patients died, and postmortem analysis of GI tissues displayed fibrinoid necrosis of terminal arterioles
within the deep mucosa, extravasation of fragmented red blood cells (RBCs) around affected vessels, and extensive crypt depletion in the tip of mucosal folds.
It has therefore become apparent that the presence of an ADAMTS13 deficiency and the resulting excess of circulating UL-VWFs leads to disseminated platelet-rich thrombi, which block terminal arterioles
. Microangiopathic haemolytic anaemia results from the mechanical destruction of red blood cells as they pass through these arterioles.
Hyaline thrombosis of the terminal arterioles
and capillaries: a hitherto undescribed disease.
The wall of the terminal arterioles is formed by flattened endothelial cells, and the fixed phagocytes are attached to the outer surface of the endothelium (Factor & Naar 1990).
Cuenot described "l'organe phagocytaire" associated with the final branches (terminal arterioles) of the hepatic artery (1903), studied the concentration of injected ink in 43 species of European decapods (1905), and is generally recognized for discovery of the ubiquitous occurrence and importance of these fixed phagocytes of the digestive gland (Johnson 1987).
Reduced tissue oxygen pressure induces relaxation of terminal arterioles and precapillary sphincters, causing them to open when the oxygen concentration falls to low levels.
In terminal arterioles, vasomotion is postulated to be due to a local vascular pacemaker-like mechanism that can be influenced by the perfusion pressure .