terfenadine


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Related to terfenadine: Astemizole

terfenadine

A non-sedating antihistamine used for allergies and viral upper respiratory tract infections. It is available in Canada, the UK, and in some other countries by prescription, but was withdrawn from US market due to cardiotoxicity.

Adverse effects
Arrhythmias (e.g., torsades de pointes, which may be due to delayed repolarisation with marked QT prolongation) and bizarre T-wave changes.

terfenadine

Seldane® A non-sedating antihistamine used for allergy and viral URIs Adverse effects Arrhythmias–eg, torsades de pointes; should not be combined with ketoconazole, an antifungal that alters its metabolism, resulting in accumulation of the parent compound, a K+ channel blocker that prolongs QT. See Allegra.

terfenadine

A non-sedating antihistamine drug used to treat ALLERGIC RHINITIS and URTICARIA. The drug can cause heart irregularities and should not be used by people with heart or liver disease. It should not be taken with grapefruit juice which increases its bioavailability.
References in periodicals archive ?
Among the employed chemical agents, E-4031, terfenadine, APV-5 and Cs were dissolved in dimethyl sulfoxide (DMSO) such that the final concentration would not exceed 1/1000.
The final data set consisted of 10,360 records representing QT interval durations for 63 patients taking terfenadine alone or with the concomitant drug in different time points of clinical studies [18].
Mattila and Paakaari [6] reported in their study of newer non-sedating antihistamines fexofenadine, loratadine, acrivastine, astemizole, cetirizine, astemizole and terfenadine however not entirely free from central effects and there at astemizole quantitative differences between them psychomotor and sleep studies in the healthy subjects in laboratory may predict that antihistamine does not cause drowsiness; but the safety margin is narrow enough to cause a central sedating effect during actual treatment.
As appearing from the loadings in Figure 2(b), (1) basic drugs, terfenadine, toremifene, nadolol, carvedilol, and haloperidol, and (2) acidic drugs, diclofenac and etodolac, have a big weight on PC1 and PC2, respectively, in comparison to the other drugs, which indicate that they play a main role in column classification.
It started at the end of 1990 with a medical description of severe cardiac side effects with the use of terfenadine (Seldane[R], Marion Merrell Dow, USA).
Effect of concomitant administration of cimetidine and ranitidine on the pharmacokinetics and electrocardiographic effects of terfenadine. Eur J Clin Pharmacol 45, 41-46.
Selective inhibitors of CYP2J2 related to terfenadine exhibit strong activity against human cancers in vitro and in vivo.
Mechanism of the cardiotoxic actions of terfenadine. JAMA 1993; 269: 1532-1536.
An in vivo drug interaction study involving the co-administration under steady-state conditions of paroxetine and terfenadine, a substrate for cytochrome CYP3A4, revealed no effect of paroxetine on terfenadine pharmacokinetics.
Fexofenadine, ([+ or -])-4-[1-hydroxy-4-[4-(hydroxyl diphenylmethyl)-1-piperidinyl]butyl]-alpha, alpha-dimethyl benzene acetic acid, an active metabolite of terfenadine, is a selective histamine [H.sub.1]-receptor antagonist and is clinically effective in the treatment of seasonal allergic rhinitis and chronic idiopathic urticaria as a first-line therapeutic agent, such as loratadine and cetirizine [1].
The vesicles are loaded with terfenadine drug and successfully utilized to transport and release drugs in zebrafish larvae, which is utilized as an emerging in vivo model system (Figure 1).
Failure of Terfenadine as a antipruritic agent in atopic dogs: Results of double blinded study.