Among the employed chemical agents, E-4031, terfenadine
, APV-5 and Cs were dissolved in dimethyl sulfoxide (DMSO) such that the final concentration would not exceed 1/1000.
The final data set consisted of 10,360 records representing QT interval durations for 63 patients taking terfenadine
alone or with the concomitant drug in different time points of clinical studies .
Mattila and Paakaari  reported in their study of newer non-sedating antihistamines fexofenadine, loratadine, acrivastine, astemizole, cetirizine, astemizole and terfenadine
however not entirely free from central effects and there at astemizole quantitative differences between them psychomotor and sleep studies in the healthy subjects in laboratory may predict that antihistamine does not cause drowsiness; but the safety margin is narrow enough to cause a central sedating effect during actual treatment.
As appearing from the loadings in Figure 2(b), (1) basic drugs, terfenadine
, toremifene, nadolol, carvedilol, and haloperidol, and (2) acidic drugs, diclofenac and etodolac, have a big weight on PC1 and PC2, respectively, in comparison to the other drugs, which indicate that they play a main role in column classification.
It started at the end of 1990 with a medical description of severe cardiac side effects with the use of terfenadine
(Seldane[R], Marion Merrell Dow, USA).
Effect of concomitant administration of cimetidine and ranitidine on the pharmacokinetics and electrocardiographic effects of terfenadine
. Eur J Clin Pharmacol 45, 41-46.
Selective inhibitors of CYP2J2 related to terfenadine
exhibit strong activity against human cancers in vitro and in vivo.
Mechanism of the cardiotoxic actions of terfenadine
. JAMA 1993; 269: 1532-1536.
An in vivo drug interaction study involving the co-administration under steady-state conditions of paroxetine and terfenadine
, a substrate for cytochrome CYP3A4, revealed no effect of paroxetine on terfenadine
Fexofenadine, ([+ or -])-4-[1-hydroxy-4-[4-(hydroxyl diphenylmethyl)-1-piperidinyl]butyl]-alpha, alpha-dimethyl benzene acetic acid, an active metabolite of terfenadine
, is a selective histamine [H.sub.1]-receptor antagonist and is clinically effective in the treatment of seasonal allergic rhinitis and chronic idiopathic urticaria as a first-line therapeutic agent, such as loratadine and cetirizine .
The vesicles are loaded with terfenadine
drug and successfully utilized to transport and release drugs in zebrafish larvae, which is utilized as an emerging in vivo model system (Figure 1).
Failure of Terfenadine
as a antipruritic agent in atopic dogs: Results of double blinded study.