Also found in: Dictionary, Wikipedia.
Related to terconazole: Yeast infection


an imidazole derivative used as a topical antifungal agent in treatment of vulvovaginal candidiasis.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.


(ter-kon-a-zole) ,


(trade name),


(trade name)


Therapeutic: antifungals
Pregnancy Category: C


Treatment of vulvovaginal candidiasis.


Affects the permeability of the fungal cell wall, allowing leakage of cellular contents. Not active against bacteria.

Therapeutic effects

Inhibited growth and death of susceptible Candida, with decrease in accompanying symptoms of vulvovaginitis (vaginal burning, itching, discharge).


Absorption: 5–16% is systemically absorbed following intravaginal administration.
Distribution: Unknown. Action is primarily local.
Metabolism and Excretion: Negligible with local application.
Half-life: Not applicable.

Time/action profile (plasma concentrations)

Intravagunknown6.6 hrunknown


Contraindicated in: Hypersensitivity to active ingredients, additives, or preservatives.
Use Cautiously in: Obstetric / / Lactation: Safety not established.

Adverse Reactions/Side Effects


  • Toxic epidermal necrolysis (life-threatening)


  • abdominal pain


  • dysmenorrhea
  • irritation
  • itching
  • vulvovaginal burning


  • anaphylaxis (life-threatening)
  • fever


Drug-Drug interaction

Not known.


Vaginal (Adults) Vaginal cream—1 applicatorful (5 g) of 0.4% cream at bedtime for 7 days or 1 applicatorful (5 g) of 0.8% cream at bedtime for 3 days. Vaginal suppositories—1 suppository (80 mg) at bedtime for 3 days.

Availability (generic available)

Vaginal cream: 0.4%, 0.8%
Vaginal suppositories: 80 mg

Nursing implications

Nursing assessment

  • Inspect involved areas of skin and mucous membranes before and frequently during therapy. Increased skin irritation may indicate sensitization and warrant discontinuation of medication.

Potential Nursing Diagnoses

Risk for infection (Indications)
Risk for impaired skin integrity (Indications)


  • Consult health care professional for proper cleansing technique before applying medication.
  • Vaginal: Applicators are supplied for vaginal administration.

Patient/Family Teaching

  • Instruct patient to apply medication as directed for full course of therapy, even if feeling better. Therapy should be continued during menstrual period.
    • Advise patient to avoid using tampons or douches while using this product.
    • Instruct patient on proper use of vaginal applicator. Medication should be inserted high into the vagina at bedtime. Instruct patient to remain recumbent for at least 30 min after insertion. Advise use of sanitary napkins to prevent staining of clothing or bedding.
    • Advise patient to consult health care professional regarding intercourse during therapy. Vaginal medication may cause minor skin irritation in sexual partner. Advise patient to refrain from sexual contact during therapy. Advise patient that this medication may weaken latex or rubber contraceptive products. Another method of contraception should be used during treatment.
    • Advise patient to report to health care professional increased skin irritation or lack of response to therapy. A second course may be necessary if symptoms persist.
    • Advise patient to thoroughly clean the applicator after each use.
    • Advise patient to notify health care professional if signs and symptoms of anaphylaxis (hives, shortness of breath, facial swelling) or rash occurs.

Evaluation/Desired Outcomes

  • Decrease in skin irritation and vaginal discomfort. Therapeutic response is usually seen after 1 wk. Diagnosis should be reconfirmed with smears or cultures before a second course of therapy to rule out other pathogens associated with vulvovaginitis. Recurrent vaginal infections may be a sign of systemic illness.
Drug Guide, © 2015 Farlex and Partners
References in periodicals archive ?
** Terconazole 0.8% cream: 5 g intravaginally for 3 days
Diagnosis: Irritant contact dermatitis (as opposed to allergic contact dermatitis) associated with the use of terconazole and clobetasol.
In vitro 48-hour to 72-hour MIC data in [micro]m/mL for the isolate were as follows: amphotericin B, >16; 5-flucytosine (5-FC), >64; ketoconazole, 0.5/0.5; fluconazole, 32/64; itraconazole, 0.5/0.5; clotrimazole, 0.06/0.25; voriconazole, 0.25/0.25; terconazole, 4/8; and posaconazole, 0.125/0.125.
Figure 3 depicts the time-series for vaginal antifungal products that have remained available only by prescription throughout the entire study period (butoconazole, nystatin, and terconazole).
(5) Boric acid was compared with nystatin, terconazole, flucytosine, itraconazole, clotrimazole, ketoconazole, fluconazole, buconazole, and miconazole.
In medicine, several potent drugs possessing triazole nucleus have been applied, like, Alprazolam (anxiolytic agent and tranquilizer), Anastrozole, Letrozole, Vorozole (antineoplastics and nonsteroidal competitive aromatase inhibitors), Estazolam (hypnotic, sedative and tranquilizer), Etoperidone (antidepressant), Fluconazole, Itraconazole, Terconazole (antifungal agents), Ribavirin (antiviral agent), Benatradin (diuretic), Rilmazafon (hypnotic, anxiolytic and used in the case of neurotic insomnia), Nefazodone (antidepressant and 5-HT2 A-antagonist), Rizatriptan (antimigraine agent), Trapidil (hypotensive), Trazodone (antidepressant, anxiolytic and selectively inhibits central serotonin uptake) and Triazolam (sedative and hypnotic) [23].
"I find terconazole is the most effective medication, and I have patients who will have to use it for 14 days as opposed to a 3- or 7-day course, and others who have to use it twice a day" Dr.
has received approval for terconazole vaginal suppositories, 80 mg.
Terconazole vaginal cream 0.4% Taro Pharmaceuticals USA
Terconazole vaginal Taro Pharmaceuticals Terazol 3 vaginal