terbutaline sulfate

terbutaline sulfate

Monovent

Pharmacologic class: Selective beta2-adrenergic receptor agonist

Therapeutic class: Bronchodilator

Pregnancy risk category B

Action

Relaxes bronchial smooth muscle by stimulating beta2-adrenergic receptors; inhibits release of hypersensitivity mediators, especially from mast cells

Availability

Injection: 1 mg/ml

Tablets: 2.5 mg, 5 mg

Indications and dosages

Bronchospasm in reversible obstructive airway disease

Adults and children older than age 12: 0.25 mg subcutaneously, repeated in 15 to 30 minutes p.r.n., up to a maximum of 0.5 mg in 4 hours. Or 2.5 to 5 mg P.O. q 6 hours t.i.d. while awake, up to a maximum of 15 mg/day in adults; 2.5 mg P.O. q 6 hours t.i.d. while awake, up to a maximum of 7.5 mg/day in children.

Dosage adjustment

• Renal impairment

Off-label uses

• Tocolytic in preterm labor

Contraindications

• Hypersensitivity to drug, its components, or sympathomimetic amines

Precautions

Use cautiously in:

• cardiovascular disorders, hypertension, arrhythmias, hyperthyroidism, diabetes mellitus, seizure disorders, glaucoma

• concurrent use of MAO inhibitors, tricyclic antidepressants, or beta-adrenergic blockers

• elderly patients

• breastfeeding patients.

Administration

• Inject subcutaneously into lateral deltoid.

Adverse reactions

CNS: tremors, anxiety, nervousness, insomnia, headache, dizziness, drowsiness, stimulation

CV: palpitations, chest discomfort, tachycardia

GI: nausea, vomiting

Skin: diaphoresis, flushing

Interactions

Drug-drug. Beta-adrenergic blockers: blockage of bronchodilating effect

MAO inhibitors, tricyclic antidepressants: potentiation of terbutaline's adverse cardiovascular reactions

Other sympathomimetic amines: additive adverse cardiovascular reactions

Patient monitoring

• Monitor vital signs.

• Assess neurologic status.

Patient teaching

• Tell patient he may take with or without food.

• Advise patient or parents to establish effective bedtime routine to minimize insomnia.

• Instruct patient or parents to space doses evenly during waking hours, to avoid taking drug at bedtime.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved

Bricanyl

A beta-adrenergic receptor agonist used for patients with COPD.
 
Indications
Asthma, bronchitis, reversible bronchospasm.
 
Adverse effects
Tremor, nervousness, palpitations, nausea, vomiting.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Different analytical techniques have been developed for determination of terbutaline sulfate and tetracycline including HPLC [89] LCMS [10] CE [11] CEMS [12] and voltammetry [13].
(APP) has received Food and Drug Administration approval for terbutaline sulfate injection, USP.
The company has also gained approval of medroxyprogesterone acetate injectable suspension, the generic equivalent of Pfizer's Depo-Provera, and of terbutaline sulfate injection, equivalent to AAI Pharmaceuticals' Brethine.
Terbutaline sulfate was prescribed, and the patient was discharged home.
Women pregnant with twins shouldn't be given a month's supply of terbutaline sulfate (Brethine) and told to take one when they have contractions, because there is no evidence that this prolongs pregnancy At least five studies show that prolonged use of oral tocolytics, including terbutaline and nifedipine (Procardia), is of no benefit for prolonging pregnancy in women with signs of preterm labor, said Dr.
I was given the drug, terbutaline sulfate (both orally and by injection), as well as betamethasone injections from my 24th week of pregnancy until his birth.
The pump is used with 3-mL syringes (3 mg of terbutaline sulfate per 3 mL).
Previous research has suggested that terbutaline sulfate increases serum glucose in pregnant women.
In March Global expanded its exclusive generics offerings with the approval of fludrocortisone acetate tablets, the equivalent of King Pharmaceutical Inc.'s Florinef, and Global continues to offer the only AB-rated generic version of Novartis Pharmaceuticals Corp.'s Brethine, with its terbutaline sulfate tablets.
[1,2] The clinical efficacy, flexibility of dosage required, ease of an administration, and relatively low cost have led to widespread use of terbutaline sulfate for tocolysis.[7,8] Terbutaline is a [[beta].sub.22]-adrenergic agonist that stimulates the [[beta].sup.2] receptor in the uterine smooth muscle, thereby activating adenylate cyclase.
PHILADELPHIA -- Global Pharmaceuticals, the multisource products marketing division of IMPAX Laboratories Inc., currently markets 15 products, including terbutaline sulfate tablets (available exclusively from Global) and the full Lipram line of pancrelipase tablets and capsules.