Alcohol has been a major teratogenic agent
Hyperthermia as a possible teratogenic agent
. / Pediatr.
However, the sensitivity of a certain in vitro test to a teratogenic agent
may depend on the underlying mechanism of action of the compound.
SUMMARY: Valproic acid, an antiepileptic drug, is a well-known teratogenic agent
; its main target organ is the neural tube, though organ malformations have also been described.
The Reference Centre for Teratogenic Agents
(Paris, France) and the manufacturer of bedaquiline approved giving this regimen because the fetus did not have major side effects.
Also, procedures involving exposing the foetus to potentially teratogenic agents
, like radiation or certain medications, should be avoided.
There was no history of trauma to head and neck region or maternal exposure to teratogenic agents
. The child was also noted for the presence of bilateral CTEV at birth.
Though the etiology may be unknown yet there may be the role of certain teratogenic agents
or angiogenic cell clusters (Differentiated from visceral mesoderm of the wall of the yolk sac] at the beginning of 3rd week of intrauterine life.
As cited in Shepard, T.H., Catalog of teratogenic agents
.1989 (6th ed.) Johns HopkinsUniversity Press, Baltimore, MD, p.
like cadmium ele ments, lead, vitamin A, cocaine and irradiation exposure are also reported to be associated with mermaid syndrome15-17 The new reproductive technology such as ICSI (Intra Cytoplasmic sperm injection) has also some association with mermaid syndrome.18
Multi-factorial etiology has been reported for congenital carpal flexural deformities like teratogenic agents
, intrauterine mal-positioning and maternal diseases during pregnancy etc.
These findings could be caused by chromosome abnormalities, single gene mutations, or teratogenic agents
. In these children, in order to ensure that the appropriate tests are ordered, a genetic consultation is important.