The risks and benefits of using a teratogenic
medication for treatment should be discussed with teens and women of reproductive age," Dr.
Hays said the researchers "are planning to also look at pregnancy and contraception rates in age-matched teens not taking teratogenic
medications using the same Medicaid claims database.
So, this could be an important pathway by which the antiepileptic drug sodium phenytoin exerts its teratogenic
influence on limb development.
In the present study, growth retardation was the most remarkable teratogenic
effect of G.
effects of ethanol vapour exposure on chick embryos.
Contraceptive provision to adolescent females prescribed teratogenic
effects of sodium valproate in mice and rats at midgestation and at term.
Although the placental membrane is relatively thick and somewhat resistant to medication transfer during the first trimester, many major teratogenic
effects still occur as a result of medication exposure during this critical organ formation period.
None of the currently available AEDs are completely safe during pregnancy, but VPA appears to be the most teratogenic
The zebrafish embryos provide very quick assessment of the teratogenic
profile of the compounds.
Components of the REMS as now planned include a patient medication guide explaining the risk of oral clefts (cleft lip with or without cleft palate) associated with first-trimester exposure in studies and pregnancy registries, a certified pharmacy network that dispenses a month's supply at a time via mail order, and a plan to educate prescribers about the teratogenic
risk and train them to prescribe the drug appropriately.
Cadmium (Cd) has been reported to be embryo-toxic and teratogenic
in a variety of animal species, but data from humans are limited.