Intraoperative analgesia was maintained with remifentanil and
tenoxicam 20 mg IV Additional remifentanil 25 [micro]g IV was administered if the mean arterial pressure (MAP) and heart rate (HR) increased >20% of the baseline in all groups.
Tenoxicam (TX) (Figure 1) is a non-steroidal anti-inflammatory drug and shows analgesic, anti-inflammatory, and antirheumatic properties.
low-dose aspirin (least severe) < ibuprofen, celecoxib < diclofenac <
tenoxicam, naproxen, indomethacin < piroxicam (most severe) While selective COX-2 inhibitors reduce the incidence of adverse GI effects, these are not entirely eliminated.
Researchers argued
Tenoxicam micro emulsion formulation showing higher cumulative percent as compared with the conventional cream and suspension of the drug.
Twenty minutes to the end of the operation,
tenoxicam (Tilcotil, Deva Ilac, Istanbul, Turkey) 20 mg IV was administered for postoperative analgesia.
Various internal standards (Naproxen sodium,
tenoxicam, diclofenac sodium, and meloxicam) were evaluated for percent recovery, sensitivity and compatibility with PX and 5-HP.
The medications used for comparison were placebo (7) and anti-inflammatory drugs such as
tenoxicam (3), rofecoxib (6), etodolac (43), indomethacin (15), corticoid dexamethasone (42), and a ginger extract (44).
Intravenous (IV) metoclopramide, NSAID (
tenoxicam) and intramuscular (IM) diclofenac were administrated to the patients for the treatment of headache.
[69] reported a stable formulation of
tenoxicam as these show high entrapment efficiency (>60%) and retention (>90%) above 30 days.
Perioperative intravenous paracetamol (lgr) and
tenoxicam (20 mg) were given.
Many previous researchers have found that intraperitoneal use of different drugs (
tenoxicam, fentanyl, lignocaine) can be helpful in relieving or reducing postoperative pain.