tenofovir


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tenofovir

 [tĕ-no´fo-vir″]
an antiretroviral agent that inhibits the viral enzyme reverse transcriptase and so inhibits replication of retroviruses; used as tenofovir disoproxil fumarate in the treatment of HIV-1 (human immunodeficiency virus-1) infection.

tenofovir

/te·no·fo·vir/ (tĕ-no´fo-vir″) an antiretroviral agent that inhibits reverse transcriptase; used as t. disoproxil fumarate in the treatment of HIV-1 (human immunodeficiency virus-1) infection.

tenofovir

(tə-nŏf′ə-vîr)
n.
An antiviral drug, C9H14N5O4P, used in the form of a prodrug (tenofovir disoproxil fumarate) to treat chronic hepatitis B and, in combination with other drugs, to treat HIV infection or to reduce the risk of HIV infection.

tenofovir

an antiretroviral agent.
indications This drug is prescribed to treat HIV-1 infection with other antiretrovirals.
contraindication Known hypersensitivity to this drug prohibits its use.
adverse effects Common adverse effects include headache, nausea, vomiting, diarrhea, flatulence, and abdominal pain.
References in periodicals archive ?
ContraVir is also developing CMX157, a highly potent analog of the successful antiviral drug tenofovir, for treatment of Hepatitis B.
Today s approval of a fixed dose combination containing a new form of tenofovir provides another effective, once daily complete regimen for patients with HIV-1 infection, said Edward Cox, M.
The pill, called Genvoya, includes doses of elvitegravir, cobicistat, emtricitabine and tenofovir alafenamide and is meant especially for patients over age 12 who weigh at least 77 pounds and have not previously been treated for HIV.
Several randomized trials have found pre-exposure prophylaxis with oral or topical tenofovir to be effective in reducing the risk of HIV acquisition, though none of them focused on women of reproductive age.
If you have a patient who's got diabetic nephropathy, a little proteinuria, and occasionally some glucosuria (4) because of intermittently uncontrolled diabetes, that might be a patient whose monitoring is going to be challenging, although their risk of tenofovir toxicity is not increased.
And because the tenofovir is delivered at the site of transmission, the ring-known as the tenofovir levonorgestrel IVR-utilizes a smaller dose than pills.
Now I know that your son isn't one of those but it's possible that tenofovir could be used as a preventative measure to stop people other than intravenous drug users getting HIV.
As in the 2010 recommendations (JAMA 2010;304:321-33), the initial choice of prophylactic therapy "continues to be based on a combination of two nucleos(t)ide reverse transcriptase inhibitors and a potent third agent," the authors noted, with the once-daily fixed-dose combination of tenofovir plus emtricitabine remaining the first choice.
The question of whether stavudine or tenofovir will ultimately save the most lives within the budget is complex.
In September 2011 oral tenofovir was discontinued from the study after a routine review determined that it was no more effective than the placebo used within the trial study group.
The tenofovir was discontinued because of the suspected Fanconi syndrome.
The candidate microbicide in the most advanced stages of effectiveness testing is tenofovir gel.