The design has a mechanism that allows for the controlled release of BMP-2 and BMP-12, which contributes to the biological recovery process of bone and tendon cells
 show that the mitochondrion-targeted antioxidant MitoQ protects against fluoroquinolone-induced oxidative stress and mitochondrial membrane damage in human Achilles tendon cells
. In cells treated with MitoQ, the oxidative stress was lower and mitochondrial membrane potential was maintained.
The team led by researcher Dr Eleanor Jones used human Achilles tendon cells
which were seeded in rat tail collagen gels.
(NYSE MKT: BTX) has developed a way to manufacture seven distinct types of cartilage, bone, and tendon cells
from human embryonic stem cells, according to a paper published last month in Regenerative Medicine.
Anitua, E., Andia, I., Sanchez, M., Azofra, J., Del Mar Zalduendo, M., De La Fuente, M., Nurden, P., and Nurden, A.T., (2005) Autologous preparations rich in growth factors promote proliferation and induce VEGF and HGF production by human tendon cells
The essence of tendinopathy is a failed healing response, with haphazard proliferation of tenocytes, some evidence of degeneration in tendon cells
and disruption of collagen fibres, and subsequent increase in non-collagenous matrix.
Eccentric contractions may also stimulate tendon cells
to produce collagen and decrease neovascularization that contributes to pain.
Loss of homeostatic tension induces apoptosis in tendon cells
: an in vitro study.