The design has a mechanism that allows for the controlled release of BMP-2 and BMP-12, which contributes to the biological recovery process of bone and
tendon cells.
[79] show that the mitochondrion-targeted antioxidant MitoQ protects against fluoroquinolone-induced oxidative stress and mitochondrial membrane damage in human Achilles
tendon cells. In cells treated with MitoQ, the oxidative stress was lower and mitochondrial membrane potential was maintained.
The team led by researcher Dr Eleanor Jones used human Achilles
tendon cells which were seeded in rat tail collagen gels.
(NYSE MKT: BTX) has developed a way to manufacture seven distinct types of cartilage, bone, and
tendon cells from human embryonic stem cells, according to a paper published last month in Regenerative Medicine.
Anitua, E., Andia, I., Sanchez, M., Azofra, J., Del Mar Zalduendo, M., De La Fuente, M., Nurden, P., and Nurden, A.T., (2005) Autologous preparations rich in growth factors promote proliferation and induce VEGF and HGF production by human
tendon cells in culture.
The essence of tendinopathy is a failed healing response, with haphazard proliferation of tenocytes, some evidence of degeneration in
tendon cells and disruption of collagen fibres, and subsequent increase in non-collagenous matrix.
Eccentric contractions may also stimulate
tendon cells to produce collagen and decrease neovascularization that contributes to pain.
Loss of homeostatic tension induces apoptosis in
tendon cells: an in vitro study.