tenascin-C


Also found in: Encyclopedia.

TNC

A gene on chromosome 9q32-q34 that encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. It plays a role in guiding migrating neurons, as well as axons, during development, synaptic plasticity, and neuronal regeneration.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

tenascin-C

(tĕn-ă′sĭn)
A glycoprotein found in the extracellular matrix that influences embryological development, tissue remodeling, and angiogenesis in infectious, inflammatory, and malignant diseases.
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
"Under closer inspection, we discovered the unexpected presence of tenascin-C in the clot.
Hase, "Secretion of tenascin-C by cultured astrocytes: regulation of cell proliferation and process elongation," Brain Research, vol.
Virtanen et al., "Tenascin-C expression in invasion border of early breast cancer: a predictor of local and distant recurrence," British Journal of Cancer, vol.
The team hope that scientists can develop new treatments that target the interaction between tenascin-C and TLR4, which may help to combat rheumatoid arthritis.
Anderson, "Tenascin-C expression and axonal sprouting following injury to the spinal dorsal columns in the adult rat," Journal of Neuroscience Research, vol.
Tenascin-C induces prolonged constriction of cerebral arteries in rats.
After cDNA was obtained from total RNA extracted from cells in each group on days 7,14, and 21, gene expression of collagen types I and III, fibronectin, tenascin-C, matrix metalloproteinase (MMP)-2, lysyl oxidase- (LOX-) 1 was detected by real-time qRT-PCR.
In our experience, the expression of tenascin-C was significantly increased in carcinomatous tissue compared to the adjacent peritumourous tissue and BPH.
Tenascin-C (TN-C) is an extracellular matrix glycoprotein [6] that is not expressed in normal adult hearts but is expressed in various myocardial diseases such as acute myocarditis [7-9], dilated cardiomyopathy [10], myocardial infarction [11], and myocardial hibernation [12].
Another example of biomarker discovery using cell-SELEX is the discovery of tenascin-C aptamers using glioblastoma cell line, U251 [18].