To better understand the mechanisms behind the altered diffusion parameters ([D.sup.*], [lambda], K, and half-life), we compared the levels of glioma chondroitin sulfate proteoglycan, tenascin C, and collagen type IV in 10- and 20-day gliomas by immunohistochemistry (Figure 4).
Different properties of glioma cell proliferation and clearance are associated with distinct glioma ECM components; in 20-day gliomas, ECM components such as chondroitin sulfate proteoglycan, tenascin C, and type IV collagen were elevated, in comparison with values obtained for the 10-day glioma group.
(21) reported that chondroitin sulfate proteoglycan, tendon, tenascin C, and type IV collagen in the glioma cell gap increase as tumor growth progresses (21,34-38).
Tenascin C (or TN-C with C for cytotactin) is a secreted extracellular matrix glycoprotein that is part of a family of three homologs along with Tenascin R and Tenascin X.
Faissner, "The extracellular matrix molecule tenascin C modulates expression levels and territories of key patterning genes during spinal cord astrocyte specification," Development, vol.