In addition, trabecular meshwork cells that express a constitutively active form of RhoA, a Rho-GTPase, were found to express increased levels of fibronectin, tenascin
C, laminin, [alpha]-smooth muscle actin, matrix assembly, actin stress fibers, and myosin light-chain phosphorylation, which are associated with the extracellular matrix .
Extracellular matrix glycoprotein tenascin-X is the largest member of the tenascin
family and induces cell detachment by means of the intracellular p38 MAP (mitogen-activated protein) kinase pathway.
Several metastasis-associated genes were identified in this study as targets of miR-335, including progenitor cell transcription factor SRY (sex determining region Y)-box 4 (SOX4) and extracellular matrix component tenascin
On the other hand, peptide elution from GBM cells was demonstrated capable of identifying 10 novel GBM-associated antigens, brevican, chitinase 3-like 2, Chondroitin sulphate proteoglycan, fatty acid-binding protein 7, insulin-like growth factor 2 messenger RNA-binding protein 3, neuroligin 4, X-linked, neuronal cell adhesion molecule, protein tyrosine phosphatase, receptortype, Z polypeptide, tenascin
C, were overexpressed in 80100% of GBM patients, making a peptide vaccine possible .
The thickened reticular basement membrane has been reported to be due to the deposition of collagens I and III, tenascin
, fibronectin, and immunoglobulin (Ig), which can lead to subepithelial fibrosis .
Also, profound disturbances in normal luminal epithelial and stromal cell differentiation occur during early pregnancy in LIF-null mice, such as failure to develop apical pinopods, no decidualization in the stroma, and low expression of decidualizing-related proteins (desmin, tenascin
, Cox-2, BMP-2 and -7, Hoxa-10) (Fouladi-Nashta et al., 2005).
AAC50945 XM_001623719.1 1e-09 Proteoglycan Dystroglycan AAH12740 XM_001621519.1 8e-25 Fibromodulin CAA51418 XM_001629115 2e-15 Fibronectin 1 NM_212476 XM_001635202.1 1e-26 Hemicentin NP_114141.2 XM_001625345.1 4e-116 Matrilin 1 NP_002370 XM_001618434 1e-42 Matrilin 2 AAH10444 XM_001636411 2e-91 Netrin 1 NP_004813 XM_001628849 3e-158 Netrin G1 NP_055732 XM_001628514 1e-145 Osteomodulin NP_005005 XM_001638987 4e-10 Osteonectin AAA60993 XM_001626392 1e-09 Podocan AAP79898 XM_001631425 6e-16 Reelin AAC51105 XM_001635471 2e-04 Syndecan 1 EAX00831 XM_001629466 0.24 Syndecan 2 NM_002998 XM_001637329 1.8 Syndecan 3 NP_055469 XM_001629466 1.9 Syndecan 4 NM_002999 XM_001641418 0.12 Tenascin
CAA39628 XM_001638256 6e-64 Vitronectin EAW51082 XM_001633180 1e-13 von Willebrand fac.
 Human genes: CYP21A2, cytochrome P450, family 21, subfamily A, polypeptide 2; STK19, serine/threonine kinase 19 (synonym for RP1); C4A, complement component 4A (Rodgers blood group); TNXB, tenascin
XB; STK19P, synonym for serine/threonine kinase 19 pseudogene (synonym for RP2); CYP21A1P, cytochrome P450, family21, subfamily A, polypeptide 1 pseudogene; TNXA, tenascin
Ferguson, "Rapid epithelialisation of fetal wounds is associated with the early deposition of tenascin
," Journal of Cell Science, vol.
Overexpression of transforming growth factor-beta 1 mRNA is associated with up-regulation of glomerular tenascin
and laminin gene expression in nonobese diabetic mice.
Briasoulis et al., "Immunohistochemical expression of extracellular matrix components tenascin
, fibronectin, collagen type IV and laminin in breast cancer: their prognostic value and role in tumour invasion and progression," European Journal of Cancer, vol.
Schor, "Evidence that tenascin
and thrombospondin-1 modulate sprouting of endothelial cells," Journal of Cell Science, vol.