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A protein that is present in the mesenchyme that surrounds epithelia in organs undergoing development in embryos; believed to participate in inducing differentiation of epithelia.
Farlex Partner Medical Dictionary © Farlex 2012

tenascin C

A secreted extracellular matrix protein encoded by TNC on chromosome 9q32-q34, which has a spatially and temporally restricted tissue distribution. It plays a key role in guidance of migrating neurons and axons during development, synaptic plasticity and neuronal regeneration.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
In addition, trabecular meshwork cells that express a constitutively active form of RhoA, a Rho-GTPase, were found to express increased levels of fibronectin, tenascin C, laminin, [alpha]-smooth muscle actin, matrix assembly, actin stress fibers, and myosin light-chain phosphorylation, which are associated with the extracellular matrix [62].
Extracellular matrix glycoprotein tenascin-X is the largest member of the tenascin family and induces cell detachment by means of the intracellular p38 MAP (mitogen-activated protein) kinase pathway.
Several metastasis-associated genes were identified in this study as targets of miR-335, including progenitor cell transcription factor SRY (sex determining region Y)-box 4 (SOX4) and extracellular matrix component tenascin C (TNC).
On the other hand, peptide elution from GBM cells was demonstrated capable of identifying 10 novel GBM-associated antigens, brevican, chitinase 3-like 2, Chondroitin sulphate proteoglycan, fatty acid-binding protein 7, insulin-like growth factor 2 messenger RNA-binding protein 3, neuroligin 4, X-linked, neuronal cell adhesion molecule, protein tyrosine phosphatase, receptortype, Z polypeptide, tenascin C, were overexpressed in 80100% of GBM patients, making a peptide vaccine possible [51].
The thickened reticular basement membrane has been reported to be due to the deposition of collagens I and III, tenascin, fibronectin, and immunoglobulin (Ig), which can lead to subepithelial fibrosis [31].
Also, profound disturbances in normal luminal epithelial and stromal cell differentiation occur during early pregnancy in LIF-null mice, such as failure to develop apical pinopods, no decidualization in the stroma, and low expression of decidualizing-related proteins (desmin, tenascin, Cox-2, BMP-2 and -7, Hoxa-10) (Fouladi-Nashta et al., 2005).
AAC50945 XM_001623719.1 1e-09 Proteoglycan Dystroglycan AAH12740 XM_001621519.1 8e-25 Fibromodulin CAA51418 XM_001629115 2e-15 Fibronectin 1 NM_212476 XM_001635202.1 1e-26 Hemicentin NP_114141.2 XM_001625345.1 4e-116 Matrilin 1 NP_002370 XM_001618434 1e-42 Matrilin 2 AAH10444 XM_001636411 2e-91 Netrin 1 NP_004813 XM_001628849 3e-158 Netrin G1 NP_055732 XM_001628514 1e-145 Osteomodulin NP_005005 XM_001638987 4e-10 Osteonectin AAA60993 XM_001626392 1e-09 Podocan AAP79898 XM_001631425 6e-16 Reelin AAC51105 XM_001635471 2e-04 Syndecan 1 EAX00831 XM_001629466 0.24 Syndecan 2 NM_002998 XM_001637329 1.8 Syndecan 3 NP_055469 XM_001629466 1.9 Syndecan 4 NM_002999 XM_001641418 0.12 Tenascin CAA39628 XM_001638256 6e-64 Vitronectin EAW51082 XM_001633180 1e-13 von Willebrand fac.
[6] Human genes: CYP21A2, cytochrome P450, family 21, subfamily A, polypeptide 2; STK19, serine/threonine kinase 19 (synonym for RP1); C4A, complement component 4A (Rodgers blood group); TNXB, tenascin XB; STK19P, synonym for serine/threonine kinase 19 pseudogene (synonym for RP2); CYP21A1P, cytochrome P450, family21, subfamily A, polypeptide 1 pseudogene; TNXA, tenascin XA (pseudogene).
Ferguson, "Rapid epithelialisation of fetal wounds is associated with the early deposition of tenascin," Journal of Cell Science, vol.
Overexpression of transforming growth factor-beta 1 mRNA is associated with up-regulation of glomerular tenascin and laminin gene expression in nonobese diabetic mice.
Briasoulis et al., "Immunohistochemical expression of extracellular matrix components tenascin, fibronectin, collagen type IV and laminin in breast cancer: their prognostic value and role in tumour invasion and progression," European Journal of Cancer, vol.
Schor, "Evidence that tenascin and thrombospondin-1 modulate sprouting of endothelial cells," Journal of Cell Science, vol.