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A protein that is present in the mesenchyme that surrounds epithelia in organs undergoing development in embryos; believed to participate in inducing differentiation of epithelia.


/te·nas·cin/ (ten´ah-sin) a glycoprotein of the extracellular matrix, isolated from a variety of embryo and adult tissues, including epithelial sites, smooth muscles, and some tumors.

tenascin C

A secreted extracellular matrix protein encoded by TNC on chromosome 9q32-q34, which has a spatially and temporally restricted tissue distribution. It plays a key role in guidance of migrating neurons and axons during development, synaptic plasticity and neuronal regeneration.


adhesive glycoprotein contributing to the cell-to-basal lamina-to-matrix interface.
References in periodicals archive ?
This analysis revealed three top-ranking pathways, which are listed in their respective order: complement and coagulation cascades (14 downregulated genes in the H group), systemic lupus erythematosus (14/16 downregulated genes in the H group) and ECM -receptor interactions (7 downregulated genes, including collagen, type IV, alpha 6 (COL4A6), tenascin C (TNC), secreted phosphoprotein 1 (SPP1), collagen, type I, alpha 2 (COL1A2), COL1A1, CD44 molecule (CD44), and ribosomal protein L26 (RPL26), and 5 upregulated genes, including integrin, beta 6 (ITGB6), syndecan 4 (SDC4), agrin (AGRN), thrombospondin 4 (THBS4), BT.
Overexpression of transforming growth factor-beta 1 mRNA is associated with up-regulation of glomerular tenascin and laminin gene expression in nonobese diabetic mice.
Another important role of the FGF family (specifically Fgf2, Fgf4, Fgf8, and Fgf9) is to up-regulate Msx1 expression for odontogenesis, as Msx/- mice have reduced expression of Bmp4, Fgf3, Lef1, Dlx2, Ptc, Syndecan-1, and tenascin [Zhang et al.
As Lee suggests, CH-8 alleles may represent chimeric TNXA/TNXB genes [TNXA, tenascin XA (pseudogene)].
Many attempts have been made to find markers that would predict the future behaviour of a non-metastatic pheochromocytoma; these markers include inmunohistochemical markers for growth capacity, angiogenesis and invasion markers (increased expression of Ki-67, p-53, VEGF, heparanase-1, Tenascin, COX-2; decreased expression of inhibin [beta]B, S-100), different cathecolamines values, necrosis, vascular and capsular invasion.
Cytokines and growth factors, such as TGF-[beta], CTGF, PDGF (platelet-derived growth factor) and endothelin-1 (ET-1), secreted in the skin and lungs activate resident fibroblasts, promoting accumulation of collagen, proteoglycans, fibronectin, tenascin, and elastin.
Table-5: Insoluble inductive signals from extra cellular matrix Peptide Sequences Parent protein Refernces RGD Fibronectin, Collagen, Fibrinogen, 127, 128 Laminin, Vitronectin, von Willebrand factor, Entactin, Tenascin, Thrombospondin YIGSR Laminin 129, 130 IKVAV Laminin 131, 132 LRE Laminin 133, 134 REDV Fibronectin 135, 136 DGEA Collagen 137, 138 GXG Thrombospondin 139, 140 VGVAPG Elastin 141, 142 Table-6: Effect of functional groups Functional groups Biological effects Carbonyl, Hydroxyl, Growth of bovine aortic endothelial cells was Carboxyl, etc.
As for the antibodies, there appeared to be more L1 labeling than tenascin.
Statistical analysis: Power calculation was performed based on previous studies that involved semiquantification of tenascin expression by immunohistochemistry.
The RCCX module is characterized by the high homology between the functional genes [RP1, CYP21A2, and TNXB (tenascin XB)] and the corresponding pseudogenes [ RP2, synonym for serine/threonine kinase 19 pseudogene (STK19P); CYP21A1P, cytochrome P450, family 21, subfamily A, polypeptide 1 pseudogene; and TNXA, tenascin XA (pseudogene)].
Kollajenin yikimi; P3 integrinlerin baglanmasi, MAP kinaz yolunun aktivasyonu ve tenascin C 'nin transkripsiyonu ile sonuclanacak olaylar zincirini baclatir.