temperature-sensitive

temperature-sensitive

living organisms that are sensitive to air temperatures outside of a narrow range, e.g. virus vaccine that does not replicate at deep body temperature, but does replicate in the respiratory tract.

temperature-sensitive (ts) mutants
strains of viruses or other microorganisms that are able to grow at certain low temperatures, say 90°F (32°C), which is referred to as the permissive temperature, but are unable to grow at higher temperatures, say 102°F (39°C), which is referred to as the nonpermissive temperature. Such conditionally lethal mutants have been much used in the genetic analysis, i.e. gene mapping, of microorganisms. At the nonpermissive temperature the protein product of a particular gene is unstable and hence nonfunctional, whereas the protein function is normal at the permissive temperature. These mutants have also been selected for use in vaccines because of their growth requirements for lower temperatures and lower pathogenicity, e.g. ts strains of bovine herpesvirus 1 which, when administered intranasally, grow on nasal mucosa but do not cause systemic illness.
temperature-sensitive proteins
proteins that are functional at higher temperatures, but not at others. See temperature-sensitive mutants (above).
References in periodicals archive ?
Named SkyCentral, the facility has 15,000 sqm of dedicated storage for temperature-sensitive goods.
5, 2015 /PRNewswire/ -- Jarden Life Sciences today published a white paper discussing available strategies to help to reduce risk and variability in temperature-sensitive pharmaceutical sampling.
The freight division of Etihad Airways, has unveiled TempCheck, its new cargo solution created to ensure the integrity of all temperature-sensitive pharmaceutical and healthcare products .
Refrigerated road transportation is a logistics process that involves the transportation of temperature-sensitive perishable goods by means of road.
To better facilitate the shipment of temperature-sensitive goods and pharmaceutical products, Cathay Pacific Cargo has signed a master agreement DoKaSch Temperature Solutions for renting the latest-technology active containers, the RKN and RAP Opticooler.
BioCision, LLC has deployed the BioT Temperature Stability Systems, a new portfolio of mobile temperature management products that support transport and handling of temperature-sensitive biomaterials.
It is easy to boil an egg, either by timing it as soon as the water begins to bubble, or, the even easier way, by putting a temperature-sensitive timer in the pan with the egg.
SkyCargo has contracted CSafe, a global provider of cool chain solutions, for the supply and service of mobile refrigeration units used for its Cool Chain Premium Service, which specialises in the transport of temperature-sensitive products, including pharmaceuticals.
SkyCargo said it has contracted CSafe for the supply and service of mobile refrigeration units used for its cool chain premium service, which specialises in the transport of temperature-sensitive products, including pharmaceuticals.
ECSLA President Hans van Leeuwen, welcoming the CCA partnership, said: "Joining forces will not just strengthen our position as the voice of the European cold storage and logistics industry in Brussels, but also put the many logistic solutions our industry is offering for handling temperature-sensitive products more into the spotlight.
The solution, which contains Telenor Connexion's embedded connectivity, allows the receiver of temperature-sensitive goods to know immediately, before accepting the shipment, if products have remained at the proper temperature for the entire trip.

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