temperature-sensitive

temperature-sensitive

living organisms that are sensitive to air temperatures outside of a narrow range, e.g. virus vaccine that does not replicate at deep body temperature, but does replicate in the respiratory tract.

temperature-sensitive (ts) mutants
strains of viruses or other microorganisms that are able to grow at certain low temperatures, say 90°F (32°C), which is referred to as the permissive temperature, but are unable to grow at higher temperatures, say 102°F (39°C), which is referred to as the nonpermissive temperature. Such conditionally lethal mutants have been much used in the genetic analysis, i.e. gene mapping, of microorganisms. At the nonpermissive temperature the protein product of a particular gene is unstable and hence nonfunctional, whereas the protein function is normal at the permissive temperature. These mutants have also been selected for use in vaccines because of their growth requirements for lower temperatures and lower pathogenicity, e.g. ts strains of bovine herpesvirus 1 which, when administered intranasally, grow on nasal mucosa but do not cause systemic illness.
temperature-sensitive proteins
proteins that are functional at higher temperatures, but not at others. See temperature-sensitive mutants (above).
References in periodicals archive ?
Delta Cargo has introduced its Pharma 4 program, which will assist customers in shipping temperature-sensitive goods to eight additional destinations across its network.
Summary: UAE carrier introduces service to ensure secure transportation of temperature-sensitive shipments
When meeting minimum volume levels, shipments can also be paired with UPS Proactive Response Secure, a financial protection service that provides coverage for these time- and temperature-sensitive shipments.
Named SkyCentral, the facility has 15,000 sqm of dedicated storage for temperature-sensitive goods.
Health Care Logistics introduces Petite Fridge, a pint-sized solution to store and secure temperature-sensitive meds for quick access when and where they're needed most.
The freight division of Etihad Airways, has unveiled TempCheck, its new cargo solution created to ensure the integrity of all temperature-sensitive pharmaceutical and healthcare products .
BioCision, LLC has deployed the BioT Temperature Stability Systems, a new portfolio of mobile temperature management products that support transport and handling of temperature-sensitive biomaterials.
It is easy to boil an egg, either by timing it as soon as the water begins to bubble, or, the even easier way, by putting a temperature-sensitive timer in the pan with the egg.
This summer, Emirates SkyCargo is carrying thousands of tonnes of temperature-sensitive commodities.
This summer Emirates SkyCargo is carrying thousands of tonnes of temperature-sensitive commodities to all corners of the globe through its international hub of Dubai.
SkyCargo said it has contracted CSafe for the supply and service of mobile refrigeration units used for its cool chain premium service, which specialises in the transport of temperature-sensitive products, including pharmaceuticals.

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