The drug, known as Temoporfin
was then introduced to the suspended droplet.
Bartunek, Glycol porphyrin derivatives and temoporfin
elicit resistance to photodynamic therapy by different mechanisms, Sci.
Grafe et al., "Tumor selectivity at short times following systemic administration of a liposomal temoporfin
formulation in a murine tumor model," Photochemistry and Photobiology, vol.
Currently, although only a few photosensitizers (temoporfin
, talaporfin, verteporfin, and 5-aminolevulinic acid), which are approved for antitumor treatment, have been proved to be effective in a wider spectrum of antitumor, they present various defects that stimulate the development of better photosensitizer candidates [5-7].
Bezdetnaya, "Interaction of liposomal formulations of meta-tetra(hydroxyphenyl)chlorin (Temoporfin
) with serum proteins: protein binding and liposome destruction," Photochemistry and Photobiology, vol.
Second-generation photosensitizers include 5-aminolevulinic acid (ALA), benzoporphyrin derivative (BPD), lutetium texaphyrin, temoporfin
(mTHPC), tinethyletiopurpurin(SnET2), and talaporfin sodium (LS11).
The cytotoxic effect of these species, through its reaction with cellular targets such as proteins, lipids, and DNA, is the rationale for the use of PDT in the treatment of cancer Most clinical work on PDT has been carried out employing Photofrin, Temoporfin, or Verteporfin, that is, porphyrin derivatives.
ALA and other PSs currently employed in clinical PDT, such as Verteporfin and Temoporfin, produce singlet oxygen during the light exposure and in addition all the PSs are retained in other sites other than the tumor, thus inducing skin photosensitivity [4-7].
Temoporfin was obtained from Biolite Pharma (Ireland, UK).
The cells were exposed to the different PSs (1 mM ALA, 3 mM Verteporfin, or 3 mM Temoporfin) in medium without serum.
argentina against PDT with the other two PSs of clinical use, Verteporfin and Temoporfin which produce singlet oxygen as the main ROS [4, 6, 7].
Second generation include 5-aminolevulinic acid (ALA), benzoporphyrin derivatives (BPD), temoporfin
(mTHPC) and talaporphin sodium (LS11).