temazepam

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Related to temazepams: Restoril

temazepam

 [tĕ-maz´ĕ-pam]
a benzodiazepine used as a sedative and hypnotic in treatment of insomnia; administered orally.

temazepam

Apo-Temazepam, Co Temazepam, Dom-Temazepam, Gen-Temazepam, Novo-Temazepam, Nu-Temazepam, PHL-Temazepam, PMS-Temazepam, Ratio-Temazepam, Restoril

Pharmacologic class: Benzodiazepine

Therapeutic class: Sedative-hypnotic

Controlled substance schedule IV

Pregnancy risk category X

Action

Depresses CNS at limbic, thalamic, and hypothalamic levels. Enhances effects of gamma-aminobutyric acid, resulting in sedation, hypnosis, skeletal muscle relaxation, and anticonvulsant and anxiolytic activity.

Availability

Capsules: 7.5 mg, 15 mg, 22.5 mg, 30 mg

Indications and dosages

Insomnia

Adults: 15 mg P.O. at bedtime p.r.n. Range is 7.5 to 30 mg.

Dosage adjustment

• Elderly or debilitated patients

Contraindications

• Hypersensitivity to drug or other benzodiazepines

• Pregnancy

Precautions

Use cautiously in:

• chronic pulmonary insufficiency, hepatic dysfunction, renal disease, psychoses, drug abuse

• history of suicide attempt or drug abuse

• elderly or debilitated patients

• breastfeeding patients

• children younger than age 15.

Administration

• Give at bedtime with or without food.

Adverse reactions

CNS: hangover, headache, dizziness, drowsiness, lethargy, fatigue, paradoxical stimulation, light-headedness, talkativeness, irritability, nervousness, confusion, euphoria, relaxed feeling, tremor, incoordination, impaired memory, nightmares, paresthesia

CV: chest pain, palpitations, tachycardia

EENT: eye irritation, pain, and swelling; photophobia; tinnitus

GI: nausea, vomiting, constipation, diarrhea, heartburn, abdominal pain, dry mouth, anorexia

Musculoskeletal: joint pain

Other: altered taste, body pain, physical or psychological drug dependence, drug tolerance

Interactions

Drug-drug. Antidepressants, antihistamines, opioid analgesics, other sedative-hypnotics: additive CNS depression

Digoxin: increased digoxin blood level, greater risk of toxicity

Probenecid: faster temazepam onset and prolonged effects

Theophylline: antagonism of temazepam's sedative effects

Drug-herbs. Chamomile, hops, kava, skullcap, valerian: increased CNS depression

Drug-behaviors. Alcohol use: additive CNS depression

Smoking: increased drug metabolism

Patient monitoring

• Monitor neurologic status carefully. Check for paradoxical reactions, especially in elderly patient.

• Watch for signs and symptoms of physical and psychological drug dependence. Stay alert for drug hoarding.

Patient teaching

• Advise patient to establish effective bedtime routine, to minimize insomnia.

• Inform patient (and significant other if appropriate) that drug may cause psychological and physical dependence and should be used only as prescribed and needed.

• Caution patient to avoid driving and other hazardous activities on day after taking drug, until he knows how it affects concentration and alertness.

• Instruct patient not to drink alcohol.

• Advise patient not to smoke or use herbs without consulting prescriber.

• Instruct patient to report suspected pregnancy.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs, herbs, and behaviors mentioned above.

temazepam

/te·maz·e·pam/ (tĕ-maz´ĕ-pam) a benzodiazepine used as a sedative and hypnotic in the treatment of insomnia.

temazepam

(tə-măz′ə-păm′)
n.
A benzodiazepine drug, C16H13ClN2O2, used for short-term treatment of insomnia.

temazepam

[temaz′əpam]
a benzodiazepine hypnotic agent.
indications It is prescribed for the relief of transient and intermittent insomnia.
contraindications Pregnancy or lactation prohibits its use. It is not recommended for patients under 18 years of age. Patients should avoid use of alcohol while also using temazepam.
adverse effects The most serious adverse effects are confusion, euphoria, anorexia, ataxia, palpitations, hallucinations, horizontal nystagmus, and paradoxic reactions.

temazepam

Temaze Pharmacology A benzodiazepine used for insomnia. See Benzodiazepine.

temazepam

A benzodiazepine drug used to treat insomnia. A brand name is Normison.

temazepam

a benzodiazepine tranquilizer.