2) Second: Should we incorporate telethonin immunohistochemistry or immunofluorescence to the investigation panel?
Conserved expression of truncated telethonin in a patient with limb-girdle muscular dystrophy 2G.
Calpain-3 is probably located in the main part of the muscle cell, and myotilin and telethonin
are located in the part of the muscle cell that allows it to contract and relax.
The Z-disk proteins include [alpha]-actinin 2, cardiac ankyrin repeat protein, muscle LIM protein, LIM binding domain 3, myozenin 2, telethonin
, and vinculin/metavinculin.
Calsarcin-1, -2 and -3 all interact with calcineurin and the Z-disc proteins [alpha]-actinin, [gamma]-filamin, myotilin, telethonin
and cipher (Faulkner et al.