tegafur

tegafur

Uftoral® Oncology An antimetabolite prodrug absorbed from the small intestine and metabolized in vivo to 5-FU. See 5-FU, Prodrug.
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China) on day 1, followed by oral administration of 50 mg of tegafur gimercil (Shandong New Time Pharmaceutical Co.
Objective: To observe clinical effects of three-dimensional conformal radiotherapy combined with Tegafur Gimeracil Oteracil Potassium chemotherapy in the treatment of patients with recurrent esophagus cancer.
Taiho Pharmaceutical's TS-1 is a combination chemotherapy that consists of tegafur (a pro-drug of 5-FU) and two agents, gimeracil and oteracil, which decrease the rate of degradation of the 5-FU anti-metabolite.
Aunque varios estudios clinicos justifican el uso de la quimioterapia adyuvante y neoadyuvante en el CG, en general no existe un consenso sobre cual deberia ser el esquema estandar, por lo que la constante es la adopcion de diferentes esquemas alrededor del mundo en donde las fluoropirimidinas como el 5-fluorouracilo (5-FU), el tegafur y la capecitabina, combinados con cisplatino o oxaliplatino, se han convertido en los farmacos de referencia para la mayoria de los tratamientos y estudios clinicos actuales.
13) Other reported treatments have been Mitomycin C, 5-Fluorouracil, Cyclophosphamide, Vincristine, Tegafur or Cisplatin, Carboplatin, Etoposide, and Vinorelbine.
Standard-dose tegafur combined with uracil is not safe treatment after severe toxicity from 5-fluorouracil or cape citabine.
11) tumors became resectable in 14 individuals (58%) after CCR; chemoradiotherapy employed carboplatin and uracil-f tegafur with 70 Gy irradiation.
The main active substance in Teysuno, tegafur, is a prodrug of a chemical called 5-fluorouracil (5-FU), meaning that it is converted in the body to 5-FU.
An example of activation is seen with the conversion of Tegafur into the active anticancer agent 5-fluorouracil (5-FU).
In another proof of principle, Hurel scientists tested the anticancer drug Tegafur using an animal-on-a-chip setup, says Baxter.
The combination drug UFT contains tegafur, which converts to 5-fluorouracil in the body, and uracil, which inhibits the enzymes that metabolize 5-fluorouracil.