tegafur

tegafur

Uftoral® Oncology An antimetabolite prodrug absorbed from the small intestine and metabolized in vivo to 5-FU. See 5-FU, Prodrug.
References in periodicals archive ?
Fujimoto et Died after 12 Oral Original al., 2018 [23] months adminis- diagnosis made tration after EUS-FNA, of TS-1 unresectable (tegafur tumor /gimeracil/ oteracil) 15.
All recruited patients were given an intravenous injection of 130 mg/m 2 oxaliplatin (Cisen Pharmaceutical Co., Ltd., China) on day 1, followed by oral administration of 50 mg of tegafur gimercil (Shandong New Time Pharmaceutical Co., Ltd., China) twice daily on days 1-14, every 3 weeks.
Petrelli et al., "Oral uracil and tegafur plus leucovorin compared with intravenous fluorouracil and leucovorin in stage II and III carcinoma of the colon: results from National Surgical Adjuvant Breast and Bowel Project Protocol C-06," Journal of Clinical Oncology, vol.
Optimizing the AC regimen (for example, using oral Tegafur to replace 5-FU injection) might help in decreasing toxicity and enhancing the therapeutic efficacy.
*; [Calcium levofolinate + tegafur + oxaliplatin] x 4, [calcium levofolinate + tegafur + irinotecan] x 4, [capecitabine + irinotecan] x 3; #: intrahepatic, peritoneal, retroperitoneal, and subcutaneous metastases.
S-1 is an oral anticancer agent containing tegafur, a prodrug of 5-fluorouracil (5-FU), and two modulators.
In a current phase I/II clinical trial, advanced metastatic GC and GEJ cancer patients receive a combination of S-1 (5FU prodrugs tegafur, gimeracil, and oteracil) and dendritic cell activated CIK (DC-CIK) [64].
Objective: To observe clinical effects of three-dimensional conformal radiotherapy combined with Tegafur Gimeracil Oteracil Potassium chemotherapy in the treatment of patients with recurrent esophagus cancer.
Taiho Pharmaceutical's TS-1 is a combination chemotherapy that consists of tegafur (a pro-drug of 5-FU) and two agents, gimeracil and oteracil, which decrease the rate of degradation of the 5-FU anti-metabolite.
The chemotherapeutic regimens used concurrently with preoperative RT employed oral UFUR (tegafur 100 mg and uracil 224 mg), intravenous high dose 5-fluorouracil (HDFL, 1500-2600 mg/m[sup.2]/day) plus leucovorin (200-300 mg/m[sup.2]/day), or oxaliplatin containing regimen (50 mg/m[sup.2]/day, FOLFOX-like), concurrently with RT for 9-10 cycles.