technetium Tc 99m sestamibi


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technetium Tc 99m sestamibi

A radioactive tracer consisting of technetium-99m linked to sestamibi. It is used to image blood flow to the heart muscle, esp. when combined with exercise or pharmacological “stress” tests. In a heart with normal blood flow, the isotope should be taken up uniformly throughout the heart muscle. Decreased uptake by regions of the heart occurs when coronary artery blood flow to those regions is blocked, e.g., by atherosclerotic plaque. Synonym: sestamibi
See also: technetium-99m
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Presence of concomitant thyroid nodules is very common and can lead to both false-negative and false positive results of technetium Tc 99m sestamibi scan.
Lantheus imaging products include the echocardiography contrast agent DEFINITY[R] Vial for (Perflutren Lipid Microsphere) Injectable Suspension, an ultrasound contrast agent for use in patients with suboptimal echocardiograms to opacify the left ventricular chamber and to improve the delineation of the left ventricular endocardial border, ABLAVAR[R] (gadofosveset trisodium), a first-in-class magnetic resonance agent indicated for the evaluation of aortoiliac occlusive disease in adults with known or suspected peripheral vascular disease, TechneLite[R] (Technetium Tc 99m Generator), Cardiolite[R] (Kit for the Preparation of Technetium Tc 99m Sestamibi for Injection), and Thallium 201 (Thallous Chloride Tl 201 Injection).
1] Recently there has been increased interest in using thallium Tl 201 and technetium Tc 99m sestamibi to assess patients with coronary artery disease.
Food and Drug Administration (FDA) has granted approval for the Company's Abbreviated New Drug Application (ANDA) for its Kit for the Preparation of Technetium Tc 99m Sestamibi Injection.
The company is home to leading diagnostic imaging brands, including Cardiolite([R]) (Kit for the Preparation of Technetium Tc 99m Sestamibi for Injection), DEFINITY([R]) Vial For (Perflutren Lipid Microsphere) Injectable Suspension, and TechneLite([R]) (Technetium Tc 99m Generator) and has nearly 700 employees worldwide with headquarters in North Billerica, Massachusetts, and offices in Puerto Rico, Canada, and Australia.