TGFBR2

(redirected from tbetaR-II)

TGFBR2

A gene on chromosome 3p22 that encodes a transmembrane kinase of the TGFB receptor subfamily of Ser/Thr protein kinases, which forms a heteromer with type-I TGF-beta receptors and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which enter the nucleus and regulate transcription of cell proliferation-related genes.

Molecular pathology
TGFBR2 mutations are associated with Marfan syndrome, Loeys-Deitz aortic aneurysm syndrome and development of various tumours.
References in periodicals archive ?
Although TbetaR-I and TbetaR-II are transmembrane serine-threonine kinases (129), they can trigger decreases in the expression of members of the Src family of tyrosine kinases (130), affecting protein tyrosine kinase signaling and hence growth regulation (131).
In apparently healthy rats, expression of TGF-[beta] and TbetaR-I and TbetaR-II is upregulated within 24 h after castration and has been linked to programmed cell death in the prostate (31).
However, in clinical samples of prostate cancer, an inverse correlation between the loss of expression of TbetaR-I and TbetaR-II and tumor grade is observed (40).