taxoid drugs

taxoid drugs

Anticancer drugs such as PACLITAXEL and docetaxel extracted from the needles of the yew Taxus baccata . These drugs enhance cellular microtubule assembly and interfere with the depolymerization of tubulin. The result is that cells cannot form the normal mitotic spindle and are unable to divide. As with most other anticancer modalities, the effect is greatest on the most rapidly-dividing cells.
Mentioned in ?
References in periodicals archive ?
Taxotere, like other taxoid drugs, inhibits cancer cell division by disrupting tubulin--the scaffolding in cells which leads to phosphorylation and inactivation of Bcl-2, a protein expressed by 60%-90% of hormone-refractory prostate cancer specimens that interferes with apoptosis.
Taxotere, like other taxoid drugs, inhibits cancer cell division by disrupting tubulin--the scaffolding in cells--which leads to phosphorylation and inactivation of Bcl-2, a protein expressed by 60%-90% of hormone-refractory prostate cancer specimens that interferes with apoptosis.