Romieu et al., "Phase II multicenter study of larotaxel (XRP9881), a novel
taxoid, in patients with metastatic breast cancer who previously received taxane-based therapy," Annals of Oncology, vol.
Rowehl et al., "Prostate cancer stem cell-targeted efficacy of a new-generation
taxoid, SBT-1214 and novel polyenolic zinc-binding curcuminoid, CMC2.24," PLoS ONE, vol.
Wilson et al., "High throughput sequencing technology reveals that the
taxoid elicitor methyl jasmonate regulates microRNA expression in Chinese yew (Taxus chinensis)," Gene, vol.
Molecular cloning and characterization of a cytochrome P450
taxoid 2a-hydroxylase involved in Taxol biosynthesis.
Tokyo, Japan, Aug 22, 2005 - (JCNN) - Aventis Pharma of the sanofi-aventis Group announced on August 19 that it has obtained additional approval for TAXOTERE Injection, its proprietary
taxoid antitumor agent, from the Ministry of Health, Labor and Welfare as of August 18.
Taxotere, like other
taxoid drugs, inhibits cancer cell division by disrupting tubulin--the scaffolding in cells which leads to phosphorylation and inactivation of Bcl-2, a protein expressed by 60%-90% of hormone-refractory prostate cancer specimens that interferes with apoptosis.
Taxotere, like other
taxoid drugs, inhibits cancer cell division by disrupting tubulin--the scaffolding in cells--which leads to phosphorylation and inactivation of Bcl-2, a protein expressed by 60%-90% of hormone-refractory prostate cancer specimens that interferes with apoptosis.
Up to now, microtubule toxin based ADCs from Creative Biolabs have been used in clinical treatment considering the potential side effects, especially toxic moieties, including auristatins, epothilone, maytansinoids,
taxoids, tubulysins, and vinorelbine.
General and recent aspects of the chemistry and structure-activity relationships of
taxoids. Curr.