Thus, the use of the assay in breast cancer care will result in a more specific use of taxanes
and a reduction of overtreatment thus avoiding serious side effects in patients and saving costs for the health care system.
This is the same target of the most widely used chemotherapy drugs in cancer, the taxanes
and vinca alkaloids.
In addition, PTX administered in the form of taxanes
displayed much shorter MRT than PTX alone, and a possible explanation is that other taxane
components may facilitate the transport of PTX out of the blood.
These include the taxanes
(paclitaxel, docetaxel) and the vinca alkaloids (vincristine, vinblastine).
(including paclitaxel and docetaxel) are the most widely used chemotherapy drug class in cancer medicine.
POMPEY, France and LUDWIGSHAFEN, Germany, February 10, 2011 /PRNewswire/ -- Novasep, a leading supplier of manufacturing solutions to the life science industries, and instrAction, a manufacturer of innovative chromatographic stationary phases for API purification processes, today announce they have expanded their worldwide strategic alliance to include the purification of taxanes
, a well-known class of anti-cancer compounds.
Although mitosis-inhibiting drugs are used successfully to treat a range of cancers, only about 50 percent of ovarian cancer patients respond to taxanes
and it is not yet possible to identify in advance which patients will benefit.
We shall discuss in this article the continuing saga of individual single gene predictors of sensitivity to anthracyclines and taxanes
, followed by some of the 'multigene' predictors of recurrence risk in EBC.
Capecitabine also is being studied as possible combination treatment with a variety of other cancer drugs, including taxanes
, vinca alkaloids, epothilones, anti-vascular endothelial growth factors, and anti-HER2/neu agents.
The data clearly show that this small molecule, oral, targeted agent, in combination with capecitabine, is effective for women whose disease has progressed on previous therapies, including anthracyclines, taxanes
and trastuzumab," said Paolo Paoletti, MD, Senior Vice President of the Oncology Medicine Development Center at GSK.
Under the agreement, EPS has agreed to use its ongoing cell factory and metabolic engineering programs to develop efficient methods for the production of paclitaxel and taxane
intermediates used to produce paclitaxel, docetaxel and other semi-synthetic taxanes
for pharmaceutical applications.
Sainte-Foy, Quebec,(TSX Venture Exchange: BIP), a leading manufacturer of naturally derived taxanes
and targeted oncology drugs, has released its results for the third quarter and nine month period ended September 30, 2003.