Secondly, the preclinical program expansion indication of PledOx in cellgiftsinducerad peripheral neuropathy (Chemotherapy Induced Peripheral Neuropathy, CIPN) caused by taxanes
. Third, activities required for PledOx market application within oxaliplatin-induced CIPN.
Many classical anti-cancer drugs act on the spindle microtubules: The taxanes
originally obtained from the yew, for example, prevent the degradation of the microtubules and thus stabilize the mitotic spindle.
QoL was assessed at six timepoints: at baseline, after administration of one and four cycles of taxanes
, before administration of FE100C, and after one and four cycles of FE100C.
Methods: We included 30 patients who received at least 6 cycles of taxane
regimen for metastatic mPC in the present study.
While no new safety concerns were identified, differences in toxicity profiles among the taxanes
It is an orally available tubulin targeting agent that has demonstrated efficacy in preclinical studies against hormone sensitive, castration resistant, as well as taxane
resistant prostate cancer.
and vinca alkaloids target that part of the cytoskeleton known as microtubules.
Unlike standard taxanes
that must be administered intravenously, tesetaxel is a capsule that is taken by mouth.
These drugs include vinca alkaloids, platinum-based drugs such as cisplatin, oxaliplatin and carboplatin, and the taxanes
docetaxel and paclitaxel.
The validity of neuropathy and neuropathic pain measures in patients with cancer receiving taxanes
Although mitosis-inhibiting drugs are used successfully to treat a range of cancers, only about 50 percent of ovarian cancer patients respond to taxanes
and it is not yet possible to identify in advance which patients will benefit.
Neratinib (HKI-272) is a potent, low-molecular-weight, orally administered, irreversible, pan-ErbB (i.e., Erb 1,2, and 4) receptor tyrosine-kinase inhibitor which has been successfully evaluated in Phase I studies involving HER2-positive metastatic breast cancer patients previously treated with trastuzumab, anthracyclines and taxanes