taxane


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taxane

(tăk′sān′)
n.
Any of a class of anticancer drugs, especially paclitaxel and docetaxel, that inhibit the division of tumor cells by binding to and interfering with the action of microtubules.

tax·ane

(taks'ān)
Any of a class of antitumor agents derived directly or semisynthetically from Taxus brevifolius, the Pacific yew (e.g., paclitaxel and docetaxel).

taxane

(tăk′sān″)
Any of a class of drugs derived from the bark of the yew tree, Taxus breviflora. Examples include paclitaxel and docetaxel. Taxanes are used to treat breast, ovarian, and other types of cancer. Side effects include bone marrow suppression, neuropathy, mucositis, and hypersensitivity reactions.

taxane

One of a group of diterpene substances derived from the Pacific yew tree Taxus brevifolia that have been found useful in cancer treatment. Taxanes have a unique action in permanently stabilizing the microtubule assembly in cells. This prevents chromosome movement and halts cell division. The taxane drugs, PACLITAXEL (Taxol) and docetaxal have been licensed for use and have been found capable of prolonging life as an adjuvant treatment in node-positive breast cancer. See also TAXOID DRUGS.
References in periodicals archive ?
Objective: SIVIDON established a prototype diagnostic assay - the ChemoPredict test - to stratify high-risk breast cancer patients and to help in deciding whether to treat the patient with standard anthracycline-based chemotherapy without taxane or taxane-containing regimens.
Results: Oral administration of taxane fractions isolated from Taxus chinensis (containing 17.
Prior therapy should have included an anthracycline and a taxane in either the adjuvant or metastatic setting unless patients were not suitable for these treatments.
Prior therapy should have included an anthracycline and a taxane unless patients were not suitable for these treatments.
Tesetaxel is the leading oral taxane in clinical development.
In addition to improving the response of some cancer to taxane, our findings add support to emerging evidence that cancer cell metabolism and mitosis functions are coupled," Ahmed Ashour Ahmed, member of the faculty at Oxford University said.
TOP2A gene amplification (11%) was exclusively observed in HER2-amplified cases (33%), was highly predictive of pathological complete response (pCR) with epirubicin but not with taxane (P=0.
The studies Frye (2009) mentioned paired capecitabine with an anthracycline and taxane sequential schedule.
Prior research has shown that adding a taxane whether during or after adjuvant chemotherapy can reduce the risk of relapse in women with operable breast cancer, according to the report in the New England Journal of Medicine (4/17).
In 50- to 69-year-olds, taxane regimens brought an 18% decrease in recurrences and a 16% reduction in breast cancer mortality, compared with anthracycline regimens.
GlaxoSmithKline recently announced that the FDA has approved TYKERB[R] (lapatinib), in combination with Xeloda[R] (capecitabine), for the treatment of patients with advanced or metastatic breast cancer whose tumors overexpress HER2 and who have received prior therapy including an anthracycline, a taxane, and trastuzumab.
In the meantime, four greenhouses are currently used to grow Jack and white pine seedlings along with the Canadian yew, a low evergreen shrub commonly known for its taxane properties, which is used in drug cancer treatments.