taxane


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taxane

(tăk′sān′)
n.
Any of a class of anticancer drugs, especially paclitaxel and docetaxel, that inhibit the division of tumor cells by binding to and interfering with the action of microtubules.

tax·ane

(taks'ān)
Any of a class of antitumor agents derived directly or semisynthetically from Taxus brevifolius, the Pacific yew (e.g., paclitaxel and docetaxel).

taxane

(tăk′sān″)
Any of a class of drugs derived from the bark of the yew tree, Taxus breviflora. Examples include paclitaxel and docetaxel. Taxanes are used to treat breast, ovarian, and other types of cancer. Side effects include bone marrow suppression, neuropathy, mucositis, and hypersensitivity reactions.

taxane

One of a group of diterpene substances derived from the Pacific yew tree Taxus brevifolia that have been found useful in cancer treatment. Taxanes have a unique action in permanently stabilizing the microtubule assembly in cells. This prevents chromosome movement and halts cell division. The taxane drugs, PACLITAXEL (Taxol) and docetaxal have been licensed for use and have been found capable of prolonging life as an adjuvant treatment in node-positive breast cancer. See also TAXOID DRUGS.
References in periodicals archive ?
Currently available taxanes must be delivered intravenously, typically at an infusion center.
There was no significant correlation between the expression levels of STHMN1 and OPN, survival, and response to taxane based regimen (p>0.
12) Because taxanes are not completely cross-resistant, (9,14) the randomized phase 2 TAXYNERGY trial explored whether an early taxane switch would benefit men who failed to achieve a sufficient PSA decline within four cycles of their original taxane therapy.
APP-111 is a platform technology that may have activity in other tumor types that have previously responded to taxanes or vinca alkaloids.
Conclusion: Together, these results support that administration of PTX in the form of taxane mixtures may become a novel approach to improve the poor bioavailability of PTX.
Prior therapy should have included an anthracycline and a taxane unless patients were not suitable for these treatments.
an intravenous taxane, is approved for 1st-line treatment of advanced gastric cancer.
The validity of neuropathy and neuropathic pain measures in patients with cancer receiving taxanes and platinums.
In addition to improving the response of some cancer to taxane, our findings add support to emerging evidence that cancer cell metabolism and mitosis functions are coupled," Ahmed Ashour Ahmed, member of the faculty at Oxford University said.
TOP2A gene amplification (11%) was exclusively observed in HER2-amplified cases (33%), was highly predictive of pathological complete response (pCR) with epirubicin but not with taxane (P=0.
A weekly dose of paclitaxel prolongs overall survival of breast cancer patients more effectively than weekly docetaxel or the standard 3-week schedule for either taxane, according to investigators of a randomized trial comparing these adjuvant regimens in nearly 5,000 women.
Prior research has shown that adding a taxane whether during or after adjuvant chemotherapy can reduce the risk of relapse in women with operable breast cancer, according to the report in the New England Journal of Medicine (4/17).