Currently available
taxanes must be delivered intravenously, typically at an infusion center.
There was no significant correlation between the expression levels of STHMN1 and OPN, survival, and response to
taxane based regimen (p>0.
12) Because
taxanes are not completely cross-resistant, (9,14) the randomized phase 2 TAXYNERGY trial explored whether an early
taxane switch would benefit men who failed to achieve a sufficient PSA decline within four cycles of their original
taxane therapy.
APP-111 is a platform technology that may have activity in other tumor types that have previously responded to
taxanes or vinca alkaloids.
Conclusion: Together, these results support that administration of PTX in the form of
taxane mixtures may become a novel approach to improve the poor bioavailability of PTX.
Prior therapy should have included an anthracycline and a
taxane unless patients were not suitable for these treatments.
an intravenous
taxane, is approved for 1st-line treatment of advanced gastric cancer.
The validity of neuropathy and neuropathic pain measures in patients with cancer receiving
taxanes and platinums.
In addition to improving the response of some cancer to
taxane, our findings add support to emerging evidence that cancer cell metabolism and mitosis functions are coupled," Ahmed Ashour Ahmed, member of the faculty at Oxford University said.
TOP2A gene amplification (11%) was exclusively observed in HER2-amplified cases (33%), was highly predictive of pathological complete response (pCR) with epirubicin but not with
taxane (P=0.
A weekly dose of paclitaxel prolongs overall survival of breast cancer patients more effectively than weekly docetaxel or the standard 3-week schedule for either
taxane, according to investigators of a randomized trial comparing these adjuvant regimens in nearly 5,000 women.
Prior research has shown that adding a
taxane whether during or after adjuvant chemotherapy can reduce the risk of relapse in women with operable breast cancer, according to the report in the New England Journal of Medicine (4/17).
