INN

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INN

 
International Nonproprietary Names, the designations recommended by the World Health Organization for pharmaceuticals.

INN

International Nonproprietary Name.

bortezomib

A proteasome inhibitor which induces apoptosis in cancer cells, and inhibits binding to stromal cells and production of growth and survival factors.

Indications
Treatment-refractory myeloma (35% response rate), mantle cell lymphoma.
 
Adverse effects
Thrombocytopaenia, fatigue, peripheral neuropathy, neutropaenia. 

INN

International Nonproprietary Names.
References in classic literature ?
To see, fixed in the rigidity of death and naked on that coarse layer of sackcloth, the man whom he had left well clad and full of meat and sin upon the threshold of a tavern, awoke, even in the thoughtless Fettes, some of the terrors of the conscience.
The machinery was not in motion, and but a few of the shop doors unbarred, when he alighted in the stable yard of the tavern, and made it his first business to order the mare four quarts of oats.
The coach rumbled up to the piazza of the tavern, followed by a thousand people; for if any man had been minding his own business till then, he now left it at sixes and sevens, to hear the news.
Hayward discovered the tavern at which this priceless beverage was to be obtained by meeting in the street a man called Macalister who had been at Cambridge with him.
When he had gone, taking his wife with him, and had settled down with her in their covered cart, the officers lay down in the tavern, covering themselves with their wet cloaks, but they did not sleep for a long time; now they exchanged remarks, recalling the doctor's uneasiness and his wife's delight, now they ran out into the porch and reported what was taking place in the covered trap.
That would be an equally fair plea in both cases,' replied Nicholas; 'but if you put it upon that ground, I have nothing more to say, than, that if I were a writer of books, and you a thirsty dramatist, I would rather pay your tavern score for six months, large as it might be, than have a niche in the Temple of Fame with you for the humblest corner of my pedestal, through six hundred generations.
Our company was soon encreased by the addition of several gentlemen from the gaming-table; most of whom, as I afterwards found, came not to the tavern to drink, but in the way of business; for the true gamesters pretended to be ill, and refused their glass, while they plied heartily two young fellows, who were to be afterwards pillaged, as indeed they were without mercy.
There was one remarkable accident attended this tavern play; for the money by degrees totally disappeared; so that though at the beginning the table was half covered with gold, yet before the play ended, which it did not till the next day, being Sunday, at noon, there was scarce a single guinea to be seen on the table; and this was the stranger as every person present, except myself, declared he had lost; and what was become of the money, unless the devil himself carried it away, is difficult to determine.
It was a neat, unpretending village tavern, and we took our repast in a quaint little room with a bed in it, decorated with some old oil paintings, which in their time had probably done duty in a Catholic chapel or monastery.
Indeed he is with reference to the tavern, what the driver is in relation to the coach and passengers: whatever happens in his sphere of action, he is quite indifferent, and perfectly easy in his mind.
Looking round, he noticed that he was standing close to a tavern which was entered by steps leading from the pavement to the basement.
Every one chattered, argued, discussed, disputed, applauded, from the gentleman lounging upon the barroom settee with his tumbler of sherry-cobbler before him down to the waterman who got drunk upon his "knock-me-down" in the dingy taverns of Fell Point.