Because inspection of the chromatograms did not reveal any major qualitative differences in the metabolite patterns of the three desmethyl compounds between the two groups of 25 and 79 specimens, the explanation for the differences in the tacrolimus assays may be quantitative differences in the metabolites relative to tacrolimus, the presence of tautomeric
forms (14) of M-III in vivo, and/or the presence of other unknown metabolites that cross-react with the MEIA (7).
Several examples of the new Optive products include Benchware(TM), a suite of desktop tools for combinatorial library enumeration, design and analysis; EA-Inventor, a novel program for de novo molecular design; and innovative technology for uniquely and accurately representing the tautomeric
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a] database: OH-acids, NH-acids, amino acids, CH-acids, SH-acids, PH-acids, and tautomeric
OH-, NH-, and SH-acids.
Pyruvic, phenyl pyruvic, and p-hydroxyphenyl pyruvic acids with these electrophoretic conditions gave wide peaks, probably because of a tautomeric
In the present work, HF and DET theoretical calculations applying standard 631++G(d,p) basis set have been carried out to investigate the tautomeric
properties of the molecule.
1A) may be due to the tautomeric
ceto-enolic equilibrium of this acid at the working pH.