Both TYRP-1 and TYRP-2 (also called DOPAchrome tautomerase
, DCT) are involved in the downstream reactions of the melanogenic pathway, aMelanocyte stimulating hormone ([alpha]-MSH), a physiological ligand that binds and acts on the G protein-coupled melanocortin 1 receptor (MC1R), potently activates the microphthalmia-associated transcription factor (MITF) to increase the expression of tyrosinase and the melanogenic enzymes TYRP-1 and TYRP-2, which ultimately induce melanin synthesis (Costin and Hearing, 2007; Park et al.
The melanogenesis pathway in the Kyoto Encyclopedia of Genes and Genomes (KEGG) includes a few expressed genes which containing tyrosinase (TYR), tyrosinase-related protein 1 (TYRP1) and dopachrome tautomerase
Plant-derived anti-inflammatory compounds affect MIF tautomerase
Further, included in the concept that portrayed "tyrosine metabolism and melanin biosynthesis" were multiple protein-protein complexes involving the proteins Dopachrome tautomerase
, Tyrosinase and Tyrosinase-related protein 1, all of which are copper binding proteins and play a critical role in the above bioprocess.
136) The same can be said for the determination of tyrosinaserelated protein-1 (TRP-1), recognized by the commercially available antibody MEL-5, and the tyrosinase-related protein-2 (TRP-2), which acts as dopachrome tautomerase
Among them the enzymatic melanosomal proteins tyrosinase, and tyrosinase-related protein-1 (TRP-1) and TRP-2 [L-3,4-dihydroxyphenylalanine (DOPA) chrome tautomerase
(DCT)] play an important role (Kobayashi et al.