Since mutant tau only appears in a small number of cases of sporadic tauopathy
, studies focused on wild-type tau in human AD may be more relevant to AD pathogenesis.
However, pathologists working in the area of autopsy neuropathology must also recognize other recently described neuropathologies of aging, including cerebral age-related TDP-43 pathology with sclerosis (CARTS) (2) and primary age-related tauopathy
However, it is becoming recognized that there is a group of human dementia patients possessing Primary Age-Related Tauopathy
(PART) whose clinical symptoms are sometimes difficult to distinguish from Alzheimer's disease.
Glucose deficit triggers tau pathology and synaptic dysfunction in a tauopathy
For example, an A-/T-/N+ profile would be expected with pathologies such as ischemic cerebrovascular disease or hippocampal sclerosis, whereas an A-/T+/N+ profile would be expected with primary age-related tauopathy
In mice genetically engineered to mimic aspects of human tauopathy
disorders, the researchers restored some of the learning and memory deficits by blocking caspase-2 activity, which suggests that some of the cognitive loss seen in tauopathies might be reversible.
Whereas in the amyloid cascade hypothesis genetic, pathologic, and biochemical evidence implicate aggregation of A[beta] as a critical early trigger in the chain of events that lead to tauopathy
, neuronal dysfunction, and dementia (16), the degree of Tau deposition correlates with the cognitive decline in AD (17,18) questioning the role of A[beta] deposition as the trigger for Tau pathogenesis.
Overall, "clinically normal adults with SNAP," the Harvard group said, "did not exhibit evidence of elevated tau levels, which suggests that this biomarker construct does not represent amyloid-independent tauopathy
," one of the bridges proposed from SNAP to AD.
Anti-inflammatory action of donepezil ameliorates tau pathology, synaptic loss, and neurodegeneration in a tauopathy
Villamil-Ortiz JG, Cardona-Gomez GP Comparative analysis of autophagy and tauopathy
related markers in cerebral ischemia and Alzheimer's disease animal models.
Furthermore, hyperphosphorylated tau (P-tau) is prone to form oligomers and toxic filaments, known as NFTs or tauopathy
Athletes: Progressive Tauopathy
Following Repetitive Head Injury, 68 J.