PKC activation with Bryostatin-1 promotes BDNF expression and secretion, and synaptogenesis, and provides protective effects against a variety of neurotoxic factors such as amyloidosis, tauopathy
, apoptosis, neuroinflammation, and oxidants.
The preclinical studies show a tau-targeted PROTAC protein degrader eliminated more than 95% of disease-causing tau protein in the brain of a well-characterized mouse tauopathy
model, following parenteral administration.
Sangamo's proprietary ZFP-TF gene regulation technology provides a differentiated approach to this problem by focusing on lowering all forms of tau at the DNA level and has the potential to provide significant therapeutic benefits for tauopathy
patients," said Adrian Woolfson, BM., B.Ch., Ph.D., Executive Vice President of Research and Development at Sangamo.
Several varied proposed theories of AD etiology are amyloid beta toxicity,  tauopathy
,  inflammation, [6,7] and oxidative stress.
Anti-tau therapies have shown promise in slowing the progression of tau pathology in animal models of tauopathy
. RG6100 is currently in Phase II clinical evaluation for its potential to slow or stop the progression of AD.
However, whether RBD is correlated with tauopathy
(2013) Synaptic alterations in the rTg 4510 mouse model of tauopathy
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Chronic traumatic encephalopathy in athletes: progressive tauopathy
after repetitive head injury.
Gerson et al., "Tau oligomers associate with inflammation in the brain and retina of tauopathy
mice and in neurodegenerative diseases," Journal of Alzheimer's Disease, vol.
Hunot et al., "Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy
," Brain, vol.
Although role of PPAR[gamma] in A[beta] mediated pathogenesis is exhaustively studied, its role in tauopathy
needs to be explored for potential mechanism for reducing the hyper-phosphorylation in-depth.
Suhara et al., "Imaging of tau pathology in a tauopathy
mouse model and in Alzheimer patients compared to normal controls," Neuron, vol.