2]N-8E12 is a humanized antibody targeting the tau protein found in neurofibrillary tangles in the brain of patients with tauopathies
such as PSP and Alzheimer's disease (AD).
The gradual establishment of neuronal degeneration in various Tauopathies
as Alzheimer~s disease could indeed result from a passage of pathological proteins neuron to neuron.
Development of grape seed polyphenolic extract with anti-oligomeric activity as a novel treatment in progressive supranuclear palsy and other tauopathies
Approximately one-half of FTLDs are tauopathies
and the other half, TDP-43 proteinopathies.
The basic science data for this agent, particularly in the tauopathies
, looks sound and the interest among investigators and among families is high.
In Alzheimer's disease, fronto-temporal dementia and some other conditions (termed tauopathies
, eg Pick's disease) tau becomes phosphorylated and joins to form filaments.
They cover the basic mechanisms of neurodegeneration, Alzheimer's disease and aging, tauopathies
, synucleinopathies, trinucleotide repeat disorders, prion disorders, frontotemporal lobal degeneration and amyotrophic lateral sclerosis/motor neuron disease, and other neurodegenerative disorders.
The researchers concluded, "These preclinical findings suggest that oral nicotinamide may represent a safe treatment for [Alzheimer's disease] and other tauopathies
, and that phosphorylation of tau at Thr231 may regulate tau stability.
Some specific topics examined include the impact of intracellular A-beta amyloid peptide in health and disease, the role of LIMK1 in neuronal degeneration in Alzheimer's disease, the multiple regulatory mechanisms of neuroprotection by astrocytes, and glycogen synthase kinase 3 as a molecular target for Alzheimer's disease and other tauopathies
These diseases, called tauopathies
, include frontotemporal dementia, Pick's disease, supranuclear palsy, and corticobasal degeneration.
These neurodegenerative tauopathies
include Pick disease and Alzheimer disease (AD), but the term also encompasses a range of other clinical conditions that share a common end-point: neurodegeneration with pathological tau accumulation (1).
Molecular Interactions among Protein Phosphatase 2A, Tau, and Microtubules: Implications for the regulation of tau phosphorylation and the development of tauopathies