tau protein


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Related to tau protein: Alzheimer disease

tau protein

microtubule-associated protein that accumulates in neurons in neurofibrillary degeneration in a wide variety of disorders including Alzheimer disease; gene for tau protein situated on chromosome 17; normal role for tau protein is to stabilize microtubules; abnormal phosphorylation of tau protein destabilizes microtubules, which causes degenerative change.

tau protein

n.
Any of several proteins that act to stabilize neuronal microtubules in the axons of brain neurons and that form abnormal tangles in the brains of people with certain neurodegenerative disorders.

tau protein

a microtubule-associated protein that forms insoluble and hyperphosphorylated aggregates in Alzheimer's disease.

tau protein

A major structural protein associated with the microtubules that form the cytoskeleton of nerve cells. An abnormal form with a shorter molecule is found in the helical filaments in senile neural plaques and in the insoluble neurofibrillary tangles of ALZHEIMER'S DISEASE. It is found in the cerebrospinal fluid of people with DEMENTIA but is present in higher concentration in Alzheimer's disease than in other forms of dementia. Abnormal tau protein binds strongly to the normal protein and the latter then become shortened by nerve cell proteolytic enzymes into the abnormal form. The latter is not split by these enzymes. It was reported in 2005 that when expression of a mutant tau gene in mice was turned off with doxycycline, lost memory was recovered to a surprising degree in spite of the presence of extensive neurofibrillary tangles.
References in periodicals archive ?
Neurofibrillary tangles (NFTs) in AD brain are consist of paired helical filaments (PHFs), which are mainly composed of hyperphosphorylated tau protein (Maccioni et al.
The use of heavy isotope-labeled tau protein as an IS, added at the very beginning of the procedure before immunoaffinity enrichment, was required to account for variability throughout sample processing.
In many forms of dementia, such as Alzheimer's disease and chronic traumatic encephalopathy caused by multiple concussions, the tau protein starts behaving badly and instead of performing its normal cellular functions, it begins accumulating and interfering with cell-to-cell communications.
Tau protein is responsible for the assembly of microtubules within the cell that form its structure.
Second, prior to the usage of diagnostic tools that helped identify amyloid beta and tau protein in living patients (as opposed to postmortem), a diagnosis could not be considered definitive, limiting the utility of the test and thereby hindering the management of the disease.
Tau protein is associated with the microtubules that form part of the cytoskeleton in neurons in the brain.
The animals had more amyloid-beta plaques, a higher load of abnormal tau protein and more severe inflammation in their brains.
Chronic stress triggers the production of the insoluble tau protein aggregates in the brain cells of mice -- the substance that leads to Alzheimer's disease.
They then compared tau protein aggregates in the brains of these mice with a control group.
Neurofibrillary tangles, which are composed of abnormally phosphorylated tau protein aggregates, appear as parallel, thickened fibrils that extend toward the apical dendrite of pyramidal neurons.
These first findings from the Domi-nantly Inherited Alzheimer Network (DIAN) study, a 6-year, cross-sectional, longitudinal study indicate that the use of PET and cerebrospinal fluid bio-markers of beta-amyloid and tau protein may allow researchers to select enriched pools of subjects for the testing of potential drug treatments, and, someday, allow clinicians to target patients with incipient disease for preventive treatment, Dr.
The drug, rember, is the first to target the "tangles" of Tau protein that develop in the brain with Alzheimer's, killing off cells needed for memory.