tau immunostaining

tau immunostaining

A histologic technique in which multiple sections of brain tissue from a postmortem examination of a patient with dementia of unknown aetiology are stained with anti-tau protein antibodies to elucidate the type of dementia.

Tau staining patterns
• Argyrophilic grain dementia
• Chromosome 17-linked neurodegeneration
• Multiple-system atrophy
• Pick’s disease
• Progressive supranuclear palsy
• Senile dementia with tangles
References in periodicals archive ?
Tau immunostaining demonstrated characteristic pathology of argyrophilic grains in the amygdala, entorhinal cortex, and hippocampus proper as well as scattered oligodendroglial "coiled" bodies in white matter.
Tau immunostaining demonstrated neurofibrillary pathology, largely restricted to limbic regions with mild hippocampal NFT pathology.
A[beta] and tau immunostaining demonstrated only sparse neuritic plaques, a Braak NFT stage of II, and a Thal phase of 3, despite the 8-year clinical history of AD superimposed on the patient's known LBD.
Intermediate" AD neuropathologies were identified by A[beta] and tau immunostaining (Thal phase 3, Braak stage V, and CERAD "sparse" neuritic plaque pathology).
Tau immunostaining of frontal cortex and hippocampus was negative.