tau immunostaining

tau immunostaining

A histologic technique in which multiple sections of brain tissue from a postmortem examination of a patient with dementia of unknown aetiology are stained with anti-tau protein antibodies to elucidate the type of dementia.

Tau staining patterns
• Argyrophilic grain dementia
• Chromosome 17-linked neurodegeneration
• Multiple-system atrophy
• Pick’s disease
• Progressive supranuclear palsy
• Senile dementia with tangles
References in periodicals archive ?
Tau immunostaining demonstrated characteristic pathology of argyrophilic grains in the amygdala, entorhinal cortex, and hippocampus proper as well as scattered oligodendroglial "coiled" bodies in white matter.
A[beta] and tau immunostaining demonstrated only sparse neuritic plaques, a Braak NFT stage of II, and a Thal phase of 3, despite the 8-year clinical history of AD superimposed on the patient's known LBD.
"Intermediate" AD neuropathologies were identified by A[beta] and tau immunostaining (Thal phase 3, Braak stage V, and CERAD "sparse" neuritic plaque pathology).
Tau immunostaining of frontal cortex and hippocampus was negative.