A target patient
population of non-del lower risk MDS patients who are naive to treatment with hypomethylating agents and lenalidomide was identified from the Phase 2 portion, and will be enrolled in the Phase 3.
This global multi-centre phase 3 study will be conducted in the target patient
population, where standard of care currently is unenhanced MRI without a contrast agent, which has lower appropriateness rating compared to any contrast enhanced procedure.
The earlier stage patients will likely be the target patient
population for this therapy and Bio-Time expects to share initial data from cohort 4 in the coming months.
"Enrollment challenges are a primary cause of delays in Phase I/II studies which involve target patient
populations, and many companies struggle with gaining access to patients while conducting trials in a safe and controlled environment," said Stanford Jhee, PharmD, corporate vice president, Early Phase Scientific Affairs at PAREXEL.
It works by generating an electromagnetic field around the target patient
anatomy during surgery so that instrument positioning is dynamically tracked throughout a procedure.
The epidemiology-based forecasting model makes use of epidemiology data gathered from research publications and primary interviews with physicians to establish the target patient
population and treatment flow patterns for individual diseases and therapies.
Reports include a dashboard summary showing a pharmacy's overall adherence rating and market benchmarking data, adherence ratings by location, adherent patient target number, adherence rating by health plan, target patient
list and patient group summary.
The authors find that there is less R&D investment in drugs that target patient
groups with longer commercialization lags, as proxied by higher five-year survival rates, for which the effective duration of patent protection is shorter.
Orphan drug designation by the FDA is granted upon recognition that the prevalence of the US target patient
population is 200,000 or less.
Having rapid and accurate microbial identification to improve and target patient
therapy made clear the potential for microbial identification where the microbes can be placed directly onto the target slide without purification steps.
Professor Tony Bjourson, director of the UU Biomedical Sciences Research Institute said: "The objective of this personalised medicine fellowship and indeed stratified medicine in general is to better target patient
drug treatment and care based on personal genetic information about a patient.
The authors searched for lactate assay values combined with critically ill patients as the target patient