Rax regulates hypothalamic tanycyte
differentiation and barrier function in mice.
Within a few weeks, they found neurons that also fluoresced, proving that these cells came from tanycyte
We propose to examine a 5th mechanism, which is unique as it is not mediated by nerve cells, but rather by specialized glial cells in the hypothalamus called tanycytes
. We have already shown that tanycytes
respond to amino acids, and that this may be via the activation of a receptor that also occurs in the taste buds of the tongue which is tuned to the "umami flavour" -the taste of L-amino acids.
Although D2 is expressed in a large number of cell types including chondrocytes and osteoblasts , cochlear and retinal cells , and tanycytes
in the walls of the third ventricle of the brain , among many others , the potential role of AT-derived D2 in metabolic disease is unclear.
For example, GFAP is known to be expressed in radial glia, subventricular zone precursor cells (neural stem cells) that may give rise to neurons, tanycytes
, and Schwann cells.
Using fluorescent tagging, the team discovered that the brain cells, known as tanycytes
, are activated within 30 seconds of certain amino acids touching the tongue.
Furthermore, specialized glial cells within the MBH known as tanycytes
release glial-derived TGF[beta]1, causing retraction of their processes and allowing for better entry of LHRH into the system of blood vessels that connect the hypothalamus with the pituitary (i.e., hypophyseal portal system) (Prevot et al.
The histogenesis of anaplastic astroblastoma is controversial; however tanycytes
, glial precursor cells, have been suggested as a potential tissue of origin [14-16].
The SVCT 2 are particularly expressed in the endocrine cells, neurons (Hediger, 2002) and hypothalamic tanycytes
(Garcia et al., 2005), thus allowing local high concentration as compared to circulating vitamin C.
A human Trx homologue, adult T leukemia-derived factor (ADF/TRX), has been found to be widely expressed in the central nervous system (CNS); this includes the subcommissural organs, ependymal, tanycytes
, and endothelial cells, as well as in the neuronal cell bodies of gerbils, albeit weakly , and the white matter astrocytes and Schwann cells in the posterior root of the human brain .
CCN2 expression has been detected not only in astrocyte somas and processes but also in a subpopulation of cortical neurons in adult rat brain, in tanycytes
, and in the grey matter of the spinal cord .
They established that a population of brain cells called "tanycytes
" behave like stem cells and add new neurons to the appetite-regulating circuitry of the mouse brain after birth and into adulthood.