tangeretin

tangeretin

A polymethoxyflavone (bioflavonoid) found in citrus fruits, which has multiple claimed health benefits. Tangeretin can induce apoptosis (programmed cell death) in Bcr-Abl+ cells via cell cycle arrest by inducing the unfolded protein response, and has synergistic cytotoxicity with imatinib.
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[6.] Pan MH, Chen WJ, Lin-Shiau SY Ho CT Lin JK, Tangeretin induces cell-cycle GI arrest through inhibiting cyclin-dependent kinases 2 and 4 activities as well as elevating Cdk inhibitors p21 and p27 in human colorectal carcinoma cells, Carcinogenesis 2002; 23: 1677-84, [CrossRef]
The major bioflavonoids found in citrus fruits are diosmin, diosmetin, hesperidin, hesperetin, naringin, naringenin, narirutin, neohesperidin, nobiletin, tangeretin, eriodictyol, and eriocitrin.
Release of naringin, tangeretin, ferulic acid, p-coumaric acid, and gallic acid was enhanced.
[18] used a HPLC-PDA method to identify 8 components (rutin, narirutin, naringin, hesperidin, neohesperidin, poncirin, nobiletin, and tangeretin) in FA, but this method was unreasonably time-consuming (60 min).
Arafa, "Tangeretin alleviates cisplatin-induced acute hepatic injury in rats: targeting MAPKs and apoptosis," PLoS One, vol.
In this study, we assessed the anti-asthmatic effects of tangeretin, an O-polymethoxylated flavone found in tangerine and other citrus fruits.
Kuo, "Hesperidin, nobiletin, and tangeretin are collectively responsible for the anti-neuroinflammatory capacity of tangerine peel (Citri reticulatae pericarpium)," Food and Chemical Toxicology, vol.
Habtemariam et al., "Neuroprotective effects of citrus fruit-derived flavonoids, nobiletin and tangeretin in alzheimer's and parkinson's disease," CNS and Neurological Disorders Drug Targets, 2017.
Kim, "Anti-inflammatory and antioxidant mechanism of tangeretin in activated microglia," Journal of Neuroimmune Pharmacology, vol.
Hwang, "Tangeretin stimulates glucose uptake via regulation of AMPK signaling pathways in C2C12 myotubes and improves glucose tolerance in high-fat diet-induced obese mice," Molecular and Cellular Endocrinology, vol.
Indeed, citrus fruits are proposed as anti-atherosclerotic agents because they are rich in flavonoids such as nobiletin, naringin, tangeretin and hesperetin.
2005) such as -pinene (Azar et al., 2011), flavonoids such as hesperidin, ferulic acid, tangeretin, sinensetin, nobiletin (Malterud and Rydland 2000; Luo et al.