tangeretin

tangeretin

A polymethoxyflavone (bioflavonoid) found in citrus fruits, which has multiple claimed health benefits. Tangeretin can induce apoptosis (programmed cell death) in Bcr-Abl+ cells via cell cycle arrest by inducing the unfolded protein response, and has synergistic cytotoxicity with imatinib.
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Meanwhile, oranges are rich in several antioxidants, including hesperidin, naringin and tangeretin, which studies show may help to lower blood cholesterol.
The present study was designed to evaluate the antihyperglycemic potential of tangeretin on the activities of key enzymes of carbohydrate and glycogen metabolism in control and streptozotocin induced diabetic rats.
In a clinical trial measuring the serum bioavailability of Sytrinol, softgels manufactured by SGTI exhibited enhanced bioavailability of the key active ingredients--specifically, the two polymethoxylated flavones tangeretin and nobiletin--compared to powder-filled, two-piece hard shell capsules.
In addition, an extract including nobiletin and tangeretin (4',5,6,7,8-pentamethoxyflavone) has been reported to show antimicrobial activity [51].
The early studies involving orange juice have identified that heptamethoxyflavone (HMF), tangeretin, and nobiletin are not only substrates for both P-glycoprotein and OATP, but also are inhibitors that decrease the bioavailability significantly of other substrates, such as fexofenadine.
Lamson and Brignall (1999) have another specific concern regarding the use of tangeretin and tamoxifen.
2000) also showed that [less than or equal to] 25 [micro]M concentrations of various phytochemicals block TCDD-induced transformation of rat liver cytosolic AhR, and these include chrysin, baicalein, apigenin, luteolin, tangeretin, galangin, kaempferol, fisetin, morin, quercetin, myricetin, tamarixetin, isorhamnetin, naringenin, eriodictyol, and hesperitin.
Individually, the best performers against both types of cells were tangeretin and nobiletin, a pair of flavonoids from tangerines.
Buffalo found that tangeretin, quercetin, and nobiletin
Regulation of adipocytokine secretion and adipocyte hypertrophy by polymethoxyflavonoids nobiletin and tangeretin.
In a clinical trial, soft gels exhibited enhanced bioavailability of the key active ingredients found in Sytrinol--the polymethoxylated flavones tangeretin and nobiletin.
Tangeretin, a citrus flavonoid, inhibits PGDF-BB-induced proliferation and migration of aortic smooth muscle cells by blocking AKT activation.