[6.] Pan MH, Chen WJ, Lin-Shiau SY Ho CT Lin JK,
Tangeretin induces cell-cycle GI arrest through inhibiting cyclin-dependent kinases 2 and 4 activities as well as elevating Cdk inhibitors p21 and p27 in human colorectal carcinoma cells, Carcinogenesis 2002; 23: 1677-84, [CrossRef]
The major bioflavonoids found in citrus fruits are diosmin, diosmetin, hesperidin, hesperetin, naringin, naringenin, narirutin, neohesperidin, nobiletin,
tangeretin, eriodictyol, and eriocitrin.
Release of naringin,
tangeretin, ferulic acid, p-coumaric acid, and gallic acid was enhanced.
[18] used a HPLC-PDA method to identify 8 components (rutin, narirutin, naringin, hesperidin, neohesperidin, poncirin, nobiletin, and
tangeretin) in FA, but this method was unreasonably time-consuming (60 min).
Arafa, "
Tangeretin alleviates cisplatin-induced acute hepatic injury in rats: targeting MAPKs and apoptosis," PLoS One, vol.
In this study, we assessed the anti-asthmatic effects of
tangeretin, an O-polymethoxylated flavone found in tangerine and other citrus fruits.
Kuo, "Hesperidin, nobiletin, and
tangeretin are collectively responsible for the anti-neuroinflammatory capacity of tangerine peel (Citri reticulatae pericarpium)," Food and Chemical Toxicology, vol.
Habtemariam et al., "Neuroprotective effects of citrus fruit-derived flavonoids, nobiletin and
tangeretin in alzheimer's and parkinson's disease," CNS and Neurological Disorders Drug Targets, 2017.
Kim, "Anti-inflammatory and antioxidant mechanism of
tangeretin in activated microglia," Journal of Neuroimmune Pharmacology, vol.
Hwang, "
Tangeretin stimulates glucose uptake via regulation of AMPK signaling pathways in C2C12 myotubes and improves glucose tolerance in high-fat diet-induced obese mice," Molecular and Cellular Endocrinology, vol.
Indeed, citrus fruits are proposed as anti-atherosclerotic agents because they are rich in flavonoids such as nobiletin, naringin,
tangeretin and hesperetin.
2005) such as -pinene (Azar et al., 2011), flavonoids such as hesperidin, ferulic acid,
tangeretin, sinensetin, nobiletin (Malterud and Rydland 2000; Luo et al.