tandem mass spectrometry

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tandem mass spectrometry (MS/MS)

a two-step technique used to analyze a sample for a predetermined set of substances, either by using a separate mass spectroscope for each step or by using the same spectroscope to perform the steps sequentially. In the first stage, a predetermined set of ions is selected for fragmentation; in the second, mass spectra are produced for the fragments. This technique is used in screening newborns for multiple metabolic disorders from a single blood sample.

multistage/mass spectrometry

An analytical procedure which recognises ions as reactive entities that can be interrogated. The prototype MS/MS instrument consists of two independently operated mass analysers linked by a reaction region in which the ion can be induced to react. Induction often occurs by collision (collision-induced dissociation) in which a selected higher-mass ion dissociates to a smaller fragment ion. In this simple conceptual instrument, three experiments are possible: precursor ion scan, product ion scan, and constant neutral loss scan. MS/MS recurring over multiple steps is known as MSn.

tandem mass spectrometry

Abbreviation: MS/MS
An analytical device that can rapidly assess the biochemical makeup of hundreds of specimens by measuring the mass-to-charge ratio of molecules. Synonym: tandem mass assay See: high-performance liquid chromatography; mass spectrometry

Patient care

It is used in clinical laboratories to screen newborn infants for metabolic disorders such as fatty acid oxidation deficiencies, organic acid disorders, and congenital adrenal hyperplasia.

See also: spectrometry
References in periodicals archive ?
Newborn mass screening and selective screening using electrospray tandem mass spectrometry in Japan.
Quantification of Total and Free Carnitine in Human Plasma by Hydrophilic Interaction Liquid Chromatography Tandem Mass Spectrometry.
It is possible to use electrospray tandem mass spectrometry for measuring acylcarnitines in blood of dogs establishing reference ranges as a valuable diagnostic tool for some inherited metabolic diseases.
Rinaldo added that to achieve the lowest possible false-positive rates, it's important to be familiar not only with tandem mass spectrometry, "but there must be experience with interpretation of complex metabolic profiles and clinical knowledge of disorders of amino acid, organic acid, and fatty acid metabolism.
Using tandem mass spectrometry for metabolic disease screening among newborns: a report of a working group.
Development of a liquid chromatography tandem mass spectrometry method for iothalamate measurement to assess renal function for potential kidney donation.
Detection of inborn errors of metabolism using tandem mass spectrometry in Omani high-risk patients.
Receipt of the 510(k) certification allows us to commercially market our phenylalanine test kit utilizing tandem mass spectrometry, which will help to improve and save the lives of newborns around the world," said Peter Coggins, Ph.
Judy Stone, who works for TPMG Kaiser Regional Laboratory, has been using tandem mass spectrometry technologies for years to conduct testing of fewer than 100 samples per day.
Contract award notice: Tandem mass spectrometry kit.
The growth of mass spectrometry and more specifically liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) [2] continues to accelerate in the clinical laboratory.