tandem duplication


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tandem duplication

a MUTATION or RECOMBINATION event producing identical adjacent segments. For example, A B C D E becomes A B C D B C D E.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
References in periodicals archive ?
Select singleton structures resulted from tandem duplication of large regions (15.5-190 kbp) in the genomes of 5 isolates (D236, D665, H624, J085, and J139) that were also flanked by copies of IS481.
Tandem duplication of D-loop and ribosomal RNA sequences in lizard mitochondrial DNA.
The company's XOSPATA has demonstrated inhibitory activity against two different mutations, FLT3 internal tandem duplication (ITD) and FLT3 tyrosine kinase domain (TKD).
These tandem duplication sequences disrupt genes at and near their insertion points and double the production of genes that happen to be copied, uninterrupted, in the middle.
Mutations in the tyrosine kinase receptor Flt3, including internal tandem duplication (ITD) mutations and tyrosine kinase domain (TKD) mutations, are the most common changes in AML, which constitutively activate the Flt3 receptor [1].
GSTKa and GSTKb are located on the same genome region, suggesting the segmental duplication or tandem duplication origin.
The molecular aberrations that have been previously studied [sup][3] in CN-AML patients include internal tandem duplications of the fms -related tyrosine kinase 3 gene ( FLT3-ITD ),[sup][4],[5],[6] the nucleophosmin gene ( NPM1 ) mutations,[sup][7] MLL partial tandem duplication ( MLL-PTD ),[sup][5],[8] E-26 transformation-specificrelated gene ( ERG) [sup][9],[10] and brain and acute leukemia, cytoplasmic ( BAALC ) expression levels.[sup][11]
[2] in prostate cancer [3], and although rare, fusion transcript has also been described due to tandem duplication as described by Jones et al.
Frew et al., "The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials," Blood, vol.
Cases with two bands were considered positive for ITD: the lower band corresponded to the normal c-kit gene while the upper band corresponded to the c-kit gene containing the internal tandem duplication (LONDON et al., 1999; ZEMKE et al., 2002).
Internal tandem duplication (ITD) mutations of FLT3 are present in approximately 20% of patients with AML, in 28% to 34% of patients with AML with normal cytogenetics, and in 40% of patients with AML with concurrent NPM1 mutation.