tamoxifen


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Related to tamoxifen: Nolvadex, Tamoxifen citrate

tamoxifen

 [tah-mok´sĭ-fen]
a nonsteroidal oral antiestrogen used as the citrate salt in the treatment and prophylaxis of breast cancer.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

tamoxifen

(tə-mŏk′sə-fĕn)
n.
A drug that is a selective estrogen receptor modulator, C26H29NOS, used in the form of its citrate primarily to treat breast cancer in women whose tumors are estrogen-dependent and to prevent breast cancer in high-risk women.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

tamoxifen

Adjuvant tamoxifen, Novaldex® Oncology A nonsteroidal anti-estrogenic used to treat early estrogen receptor–ER-positive breast CA; prophylactic tamoxifen may used in postmenopausal ♀ at high risk for breast CA Other benefits ↓ Serum lipids, ↓ risk of CAD; it maintains bone mass and ↓ osteoporosis Cons ↑ risk of endometrial CA. See Breast cancer, Chemokine, STAR. Cf Raloxifene.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

tamoxifen

A drug that blocks oestrogen receptors and is useful in the treatment of certain cancers, especially breast cancer. Research involving 37,000 women has shown that tamoxifen substantially improves the survival figures after breast cancer and substantially reduces the probability of cancer in the other breast. The drug also stimulates egg production from the ovaries and can be used to treat infertility. It is on the WHO official list. Brand names are Nolvadex and Tamofen.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

Patient discussion about tamoxifen

Q. Hot flashes while on tamoxifen - is there anything to do? Hello, Last year I was diagnosed with breast cancer, and after surgery and radiation, I was given tamoxifene. In the beginning it was OK, but now I have hot flashes. Usually I can to hold my self until It passes, but some times (like during work) it’s just so bothering- is there anything I can do to make these flashes go?

A. Just a short update, I took Riki's advice and went to see my doctor a couple of days ago - now I just have to wait and see if the medicine he gave me will do the trick.

Q. I heard about tamoxifen. Should women who have an increased risk of breast cancer take tamoxifen?

A. Dear Elizabeth, women with an increased risk of breast cancer can think about taking tamoxifen to reduce their risk. As with any medical procedure or treatment, the decision to take tamoxifen is a personal one in which the benefits and risks must be discussed with your doctor. The balance of these benefits and risks will vary depending on a woman's personal health history and how much importance she puts on the benefits and risks. Even if a woman has an increased risk of breast cancer, tamoxifen therapy may not be right for her. Any woman who is thinking about tamoxifen therapy should talk with her doctor about her personal health situation to make the best decision.

Q. Want to know how this tamoxifen works to fight cancer as my lump is removed and is there any side effects? Hi… I am 26 years lady, my breast cancer lump is removed and after my chemo I am on tamoxifen now……wanted to know how this tamoxifen works to fight cancer as my lump is removed now and is there any side effects associated with it?

A. With, Tamoxifen uterine cancer risk is there to some. As Breast cancers have estrogen receptors which stimulate the cancer cell to grow and tamoxifen inhibits. If post surgery you have any incidence of cancer reversal due to estrogen then tamoxifen will inhibit and will complete your treatment.

More discussions about tamoxifen
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References in periodicals archive ?
"The addition of ovarian suppression to tamoxifen resulted in significantly higher eight-year rates of both disease-free and overall survival than tamoxifen alone," the authors write.
By 1988 the CRUK-funded group had pooled the results of 28 tamoxifen trials from around the world, involving more than 16,000 participants, and showed that women over the age of 50 treated with tamoxifen had much better outcomes than those given chemotherapy.
In addition, there are few reports about tamoxifen-induced ovarian hyperstimulation in Japanese women, and this is the first report to treat ovarian hyperstimulation without abandoning tamoxifen in Japanese women with breast cancer.
Tamoxifen is a non-steroidal agent that binds to estrogen receptors (ER), causes a conformational change in the receptor.
"Tamoxifen's effect on ceramides led us to wonder if, when it is administered in patients, the drug would also affect neutrophil behavior," said first author Ross Corriden, project scientist in the UC San Diego School of Medicine Department of Pharmacology.
And when I see a premenopausal woman who is 48 and who's got a small, screen-detected, nonaggressive breast cancer, I will feel very comfortable that she can do quite well with tamoxifen alone."
Tamoxifen is a weak estrogen and is classified as a SERM (selective estrogen receptor modulator).
Taking these antidepressants along with tamoxifen interferes with the body's ability to metabolize endoxifen.
In the trial of 12,894 women, investigators randomly assigned those who had received tamoxifen for 5 years to another 5 years of therapy or to no additional therapy, regardless of ER status.
The new trial, called Atlas, looked at the effect of taking tamoxifen for a total of 10 years after diagnosis.
In theory, patients with normal CYP2D6 activity (extensive metabolizers, EM) would have a better clinical response to tamoxifen than those with moderately reduced (intermediate metabolizers, IM) or severely reduced/absent CYP2D6 activity (poor metabolizers, PM).
The large study, reported in The Lancet Oncology today, found the benefits of taking a five-year course of tamoxifen continue for another 10 years in women who have hormone-sensitive breast cancer.