tamoxifen


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Related to tamoxifen: Nolvadex, Tamoxifen citrate

tamoxifen

 [tah-mok´sĭ-fen]
a nonsteroidal oral antiestrogen used as the citrate salt in the treatment and prophylaxis of breast cancer.

tamoxifen

/ta·mox·i·fen/ (tah-mok´sĭ-fen) a nonsteroidal antiestrogen used as the citrate salt in the prophylaxis and treatment of breast cancer.

tamoxifen

(tə-mŏk′sə-fĕn)
n.
A drug that is a selective estrogen receptor modulator, C26H29NOS, used in the form of its citrate primarily to treat breast cancer in women whose tumors are estrogen-dependent and to prevent breast cancer in high-risk women.

tamoxifen

[təmok′səfin]
a nonsteroidal antiestrogen used in the palliative treatment of advanced breast cancer in premenopausal and postmenopausal women whose tumors are estrogen dependent. Tamoxifen has also been used to reduce the incidence of breast cancer in women with a high risk for developing it and for treating gynecomastia, precocious puberty, and other instances of estrogen excess.

tamoxifen

Adjuvant tamoxifen, Novaldex® Oncology A nonsteroidal anti-estrogenic used to treat early estrogen receptor–ER-positive breast CA; prophylactic tamoxifen may used in postmenopausal ♀ at high risk for breast CA Other benefits ↓ Serum lipids, ↓ risk of CAD; it maintains bone mass and ↓ osteoporosis Cons ↑ risk of endometrial CA. See Breast cancer, Chemokine, STAR. Cf Raloxifene.

tamoxifen

A drug that blocks oestrogen receptors and is useful in the treatment of certain cancers, especially breast cancer. Research involving 37,000 women has shown that tamoxifen substantially improves the survival figures after breast cancer and substantially reduces the probability of cancer in the other breast. The drug also stimulates egg production from the ovaries and can be used to treat infertility. It is on the WHO official list. Brand names are Nolvadex and Tamofen.

tamoxifen

hormone antagonist used to treat/prevent breast cancer; patients on tamoxifen are prone to thromboembolism, especially postsurgery or following prolonged rest

tamoxifen

an antiestrogen used as the citrate in the treatment of disseminated mammary cancer.

Patient discussion about tamoxifen

Q. Hot flashes while on tamoxifen - is there anything to do? Hello, Last year I was diagnosed with breast cancer, and after surgery and radiation, I was given tamoxifene. In the beginning it was OK, but now I have hot flashes. Usually I can to hold my self until It passes, but some times (like during work) it’s just so bothering- is there anything I can do to make these flashes go?

A. Just a short update, I took Riki's advice and went to see my doctor a couple of days ago - now I just have to wait and see if the medicine he gave me will do the trick.

Q. I heard about tamoxifen. Should women who have an increased risk of breast cancer take tamoxifen?

A. Dear Elizabeth, women with an increased risk of breast cancer can think about taking tamoxifen to reduce their risk. As with any medical procedure or treatment, the decision to take tamoxifen is a personal one in which the benefits and risks must be discussed with your doctor. The balance of these benefits and risks will vary depending on a woman's personal health history and how much importance she puts on the benefits and risks. Even if a woman has an increased risk of breast cancer, tamoxifen therapy may not be right for her. Any woman who is thinking about tamoxifen therapy should talk with her doctor about her personal health situation to make the best decision.

Q. Want to know how this tamoxifen works to fight cancer as my lump is removed and is there any side effects? Hi… I am 26 years lady, my breast cancer lump is removed and after my chemo I am on tamoxifen now……wanted to know how this tamoxifen works to fight cancer as my lump is removed now and is there any side effects associated with it?

A. With, Tamoxifen uterine cancer risk is there to some. As Breast cancers have estrogen receptors which stimulate the cancer cell to grow and tamoxifen inhibits. If post surgery you have any incidence of cancer reversal due to estrogen then tamoxifen will inhibit and will complete your treatment.

More discussions about tamoxifen
References in periodicals archive ?
The small blue cells identified in our study are not endometrial in origin, an important diagnostic distinction in that the presence of endometrial cells in the Pap tests of patients receiving tamoxifen indicates a higher risk of endometrial adenocarcinoma.
Tamoxifen is a non-steroidal agent that binds to estrogen receptors (ER), causes a conformational change in the receptor.
To test their theory, the researchers incubated human neutrophils with tamoxifen.
And when I see a premenopausal woman who is 48 and who's got a small, screen-detected, nonaggressive breast cancer, I will feel very comfortable that she can do quite well with tamoxifen alone.
Tamoxifen is a weak estrogen and is classified as a SERM (selective estrogen receptor modulator).
Taking these antidepressants along with tamoxifen interferes with the body's ability to metabolize endoxifen.
In the trial of 12,894 women, investigators randomly assigned those who had received tamoxifen for 5 years to another 5 years of therapy or to no additional therapy, regardless of ER status.
Researchers recruited almost 7,000 women with oestrogen-sensitive cancer who were completing five years of tamoxifen treatment.
A review of 17 independent retrospective studies of CYP2D6 and tamoxifen response evaluated several possible factors that might explain some of this discrepancy (Oncologist 2012;17:620-30).
Dr Ian Lewis, Tenovus' associate director of research, said: "Nearly 40 years ago, researchers at the Tenovus Institute for Cancer Research in Cardiff were among the first to show that tamoxifen, a drug originally designed as a potential but ineffective contraceptive, was actually a highly-effective drug for the treatment of the majority of breast cancers.
Compliance for five years of tamoxifen ranges from 50 to 90 percent," says Dr.