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talc granulomaA foreign-body giant cell reaction of three types.
Talc granuloma occurrences
Post-surgical The peritoneum, body cavities, or tissues, due to contamination by surgical glove lubricants, eg talc, lycopodium, mineral oil rice, or corn starch, or by cellulose fibers from disposable gauze pads, drapes, gowns and other paper products
IV exposure Various organs, commonly the lungs of IV drug abusers, where the substance of abuse, usually a white powder–eg cocaine, has been 'cut' with starch or talcum powder; the granulomas measure 14-50 µm in diameter, and are located in eccentric patches of connective tissue and fibrous septae; the lungs have mild medial hypertrophy of the pulmonary arteries, but are not associated with pulmonary hypertension
Talcum powder Penetrates to subepithelial tissues of external genitalia, causing TGs of the vagina, cervix, uterus, fallopian tubes, urethra and bladder