tacrine


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Related to tacrine: Rivastigmine, Galantamine, Metrifonate

tacrine

 [tak´rēn]
a cholinesterase inhibitor used to improve cognitive performance in treatment of dementia of the Alzheimer type; used as the hydrochloride salt.

tac·rine

(tak'rēn),
An anticholinesterase agent with nonspecific CNS stimulatory effects; used in early stages of Alzheimer disease.

tacrine

(tăk′rēn, -rĭn)
n.
A drug, C13H14N2, used in its hydrochloride form to treat memory loss and other cognitive deficits in people with Alzheimer's disease.

tacrine

Cognex® Neurology An aminoacridine-type cholinesterase inhibitor reported to improve–slightly–the cognitive status of Pts with Alzheimer's disease Adverse effects Hepatotoxicity

tac·rine

(tak'rēn)
An anticholinesterase agent with nonspecific stimulatory effects on the central nervous system.

tacrine

An acetylcholinase inhibitor drug that has been found to be of value in 30–40 per cent of people with mild-to-moderate Alzheimer's disease. The drug has been approved for use in the USA but, because of its side effects, not in the UK. Newer acetylcholinase inhibitors are being developed.

Tacrine

A drug commonly prescribed for Alzheimer's disease that provides temporary improvement in cognitive functions for some patients with mild-to-moderate forms of the disease.
Mentioned in: Dementia

tac·rine

(tak'rēn)
An anticholinesterase agent with nonspecific central nervous system stimulatory effects; used in early stages of Alzheimer disease.
References in periodicals archive ?
Tacrine is another piperidine ring containing drug used for the managent of Alzheimer's disorder [9, 10].
The current therapy for AD is based on the administration of AChE inhibitors, such as tacrine, rivastigmine, donepezil, and galantamine [1].
Alzheimer's activists have coalesced particularly around the battle for the approval of a promising drug, tacrine. Ageism may be a factor in the Food and Drug Administration's refusal to expedite tacrine's approval as it did for AIDS drugs.
[8,9] Therefore, one of the most current treatments of AD is administrating acetylcholine esterase inhibitors such as tacrine and donepezil.
Preliminary research suggests that this over-the-counter natural medicine may be as effective as donepezil and tacrine, the medications currently used for treating AD, and there is some indication that it may offer antioxidant and neuroprotective benefits as well.
In vitro studies have shown that huperzine A's acetyl-cholinesterase-inhibiting activity exceeds that of tacrine and galantamine, and animal studies have found that the compound has greater bioavailability and crosses the blood-brain barrier more easily than tacrine or donepezil (Curr.
The drugs approved for use with patients with dementia are tacrine (Cognex[R]), donepezil (Aricept[R]), rivastigmine (Exelon[R]), and galantamine (Reminyl[R]).
Aricept (donepezil) inhibits acetylcholinesterase only; Cognex (tacrine) also inhibits butyrylcholinesterase but is no longer prescribed because it causes liver toxicity, said Dr.
The section on tacrine is of historical interest only to the British reader grappling with the implications of donepezil.
In recent years two medications, tacrine and donepezil, have been approved for use in AD.
Rabins: A drug called tacrine has raised interest of late.