tachyphylaxis


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tach·y·phy·lax·is

(tak'i-fī-lak'sis),
Rapid appearance of progressive decrease in response to a given dose after repetitive administration of a pharmacologically or physiologically active substance.
[tachy- + G. phylaxis, protection]
Farlex Partner Medical Dictionary © Farlex 2012

tachyphylaxis

(tăk′ə-fĭ-lăk′sĭs)
n. pl. tachyphy·laxes (-fĭ-lăk′sēz)
1. Rapid desensitization to a toxic substance produced by inoculation with a series of small doses.
2. A rapidly decreasing response to a drug following administration of the initial doses.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

tachyphylaxis

A decrease in response to a drug due to prior exposure to the agent, which may be countered by increasing the dose. Tachyphylaxis has been reported in some women taking subcutaneous hormone-replacement therapy, in whom menopausal symptoms recur in the face of normal serum oestrogen levels.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

tach·y·phy·lax·is

(tak'i-fi-lak'sis)
Rapid appearance of progressive decrease in response to a given dose after repetitive administration of a pharmacologically or physiologically active substance.
[tachy- + G. phylaxis, protection]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

tach·y·phy·lax·is

(tak'i-fī-lak'sis)
Rapid appearance of progressive decrease in response to a given dose after repetitive administration of a pharmacologically or physiologically active substance.
[tachy- + G. phylaxis, protection]
Medical Dictionary for the Dental Professions © Farlex 2012
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References in periodicals archive ?
Meier, "Rapid tachyphylaxis of the glucagon-like peptide 1-induced deceleration of gastric emptying in humans," Diabetes, vol.
Tezel, "Is there tachyphylaxis to intravitreal anti-vascular endothelial growth factor pharmacotherapy in age-related macular degeneration?," Ophthalmology, vol.
Partial tachyphylaxis to somatostatin (SST) analogues in a patient with acromegaly: the role of SST receptor desensitisation and circulating antibodies to SST analogues.
When these analogs are used for more than 12 months, tachyphylaxis may occur [12].
(16) Topical steroids are effective for managing both AD and psoriasis, although there is a lack of long-term studies on associated tachyphylaxis (reduced reaction to a drug) and systemic adverse effects.
Some patients experience a loss of drug response over time (tachyphylaxis) or a depressive recurrence while taking an antidepressant.
Moreover, pharmacokinetic and/or pharmacodynamic tolerance effects resulting from chronic exposure to antidepressants have also been hypothesized to be related to the development of antidepressant tachyphylaxis or tolerance (loss of antidepressant efficacy when in maintenance treatment with the same drug and dosage regimen) [36, 37].
In the ED, observations of clinical features are more relevant to the severity of drug intoxication than estimates of abused doses because repeated administration of the drugs results in tachyphylaxis. [sup][13]
This the reason that the presence of perianal wounds after hemorrhoidectomy may significantly affect the kinetics of 0.2% GTN absorption and its activity may be reduced by tachyphylaxis. This may be one of the important factors explaining inferior pain relief obtained in this group.
Patients treated with DR-prednisone maintained their morning stiffness responses with no evidence of tachyphylaxis for up to 1 year.
In general, in the early period, infection, nerve damage, hemorrhage, seroma, intervention area pain, electrode migration, negative impact on bowel movements, long-term body reaction to the system, development of wounds in the skin owing to erosion, removal of the battery and connections, infection, problems regarding battery or electrode, programming problems, and tachyphylaxis development might be observed.
Tachyphylaxis can develop within 6 weeks of medication use, limiting long-term efficacy.