tachyphylaxis


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tach·y·phy·lax·is

(tak'i-fī-lak'sis),
Rapid appearance of progressive decrease in response to a given dose after repetitive administration of a pharmacologically or physiologically active substance.
[tachy- + G. phylaxis, protection]

tachyphylaxis

/tachy·phy·lax·is/ (-fĭ-lak´sis)
1. rapid immunization against the effect of toxic doses of an extract or serum by previous injection of small doses of it.
2. rapidly decreasing response to a drug or physiologically active agent after administration of a few doses.tachyphylac´tic

tachyphylaxis

(tăk′ə-fĭ-lăk′sĭs)
n. pl. tachyphy·laxes (-fĭ-lăk′sēz)
1. Rapid desensitization to a toxic substance produced by inoculation with a series of small doses.
2. A rapidly decreasing response to a drug following administration of the initial doses.

tachyphylaxis

[tak′ēfəlak′sis]
Etymology: Gk, tachys + phylax, guard
1 (in pharmacology) a phenomenon in which the repeated administration of some drugs results in a rapidly appearing and marked decrease in effectiveness.
2 also called mithridatism, (in immunology), a rapidly developing immunity to a toxin because of previous exposure, such as from previous injection of small amounts of the toxin (named for Mithridates VI who used the technique to survive an assassination attempt).

tachyphylaxis

A decrease in response to a drug due to prior exposure to the agent, which may be countered by increasing the dose. Tachyphylaxis has been reported in some women taking subcutaneous hormone-replacement therapy, in whom menopausal symptoms recur in the face of normal serum oestrogen levels.

tach·y·phy·lax·is

(tak'i-fi-lak'sis)
Rapid appearance of progressive decrease in response to a given dose after repetitive administration of a pharmacologically or physiologically active substance.
[tachy- + G. phylaxis, protection]

tachyphylaxis (ta·kē·flakˑ·sis),

n swiftly developed tolerance to a drug or toxin achieved through repeated exposure to minute doses.

tach·y·phy·lax·is

(tak'i-fī-lak'sis)
Rapid appearance of progressive decrease in response to a given dose after repetitive administration of a pharmacologically or physiologically active substance.
[tachy- + G. phylaxis, protection]

tachyphylaxis (tak´əfəlak´sis),

n 1. the rapid development of tolerance on administration of closely spaced successive doses of a drug or poison.
2. a decreasing response that follows consecutive injections at short intervals.

tachyphylaxis

1. rapid immunization against the effect of toxic doses of an extract by previous injection of small doses of it.
2. rapidly decreasing response to a drug or physiologically active agent after administration of a few doses.
References in periodicals archive ?
Proton pump inhibitors (PPIs) are effective at achieving acid suppression and do not cause tachyphylaxis.
Chronic sildenafil improves erectile function and endothelium-dependent cavernosal relaxations in rats: lack of tachyphylaxis.
5 mg Clonazepam 30 minutes prior to bed time and for more than 90% of patients this dose remains effective without tachyphylaxis.
There was no evidence of tachyphylaxis, or rebound.
46) Tachyphylaxis is not seen with this drug and it is probably due to stromal apoptotic effect or more central mediated effects.
Tachyphylaxis is believed to result from depleted concentrations of neurotransmitters (Riviere, Gentry & Owens 2000; Gygi et al.
In patients who do have renal dysfunction, alterations in calcium metabolism may cause widespread tissue calcification that affects the arterial bed, so-called vascular tachyphylaxis.
2] agonists will also block EIA, but tachyphylaxis and safety concerns mitigate against their use as monotherapy.
The initial response to octreotide is good in most cases of HI, but tachyphylaxis develops after a few doses, rendering therapy inadequate for long-term use.