tachykinin


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Related to tachykinin: tachykinin 2, neurokinin 2

tach·y·ki·nin

(tak'i-kī'nin),
Any member of a group of polypeptides, widely scattered in vertebrate and invertebrate tissues, which have in common four of the five terminal amino acids: Phe-Xaa-Gly-Leu-Met-NH2; pharmacologically, they all cause hypotension in mammals, contraction of gut and bladder smooth muscle, and secretion of saliva.
[G. tachys, swift, + kineō, to move, + -in]

tachykinin

/tachy·ki·nin/ (-ki´nin) any of a family of peptides structurally and functionally similar to substance P; all are potent, rapidly acting secretagogues and cause smooth muscle contraction and vasodilation.

tachykinin

tachykinin

(tăk″kī′nĭn) [″ + ″],

TK

Any of a large family of peptides that function as neurotransmitters in the central and peripheral nervous systems. They have extraneuronal activity in other body tissues. Their diverse biological actions are mediated through cellular G proteins.
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References in periodicals archive ?
Tachykinins and their receptors: contributions to physiological control and the mechanisms of disease.
Tachykinins (TACs) are characterized by pharmacological similarity to their endogenous inflammatory mediator, bradykinin, yet TACs are not of similar structure to that of bradykinin.
Effects of central administration of tachykinin receptor agonists and antagonists on plus-maze behavior in mice.
Primary afferent tachykinins are required to experience moderate to intense pain.
Airway neurogenic inflammation is caused by tachykinins released from sensory neuron peripheral nerve endings within the airways, and is characterized by plasma protein extravasation, airway smooth muscle contraction and increased secretion of mucus (25, 108).
The pharmacology of GR203040, a novel, potent and selective non-peptide tachykinin NK1 receptor antagonist.
Substance P (SP), a neuropeptide and member of the tachykinin family, has potent effects on airway smooth muscle tone, vascular permeability, and mucus secretion (Barnes et al.
Further evidence for the involvement of tachykinin receptor subtypes in formalin and capsaicin models of pain in mice.
Tachykinin peptides, receptors, and peptidases in airway disease.
Furthermore, elevated levels of sensory nerve-mediated tachykinin substance P were found in nasal lavage fluid (NAL) of patients with chronic cough and increased capsaicin cough sensitivity (Cho et al.
Tachykinin NK1 and receptor-mediated control of peristaltic propulsion in the guinea-pig small intestine in vivo.