tachykinin


Also found in: Dictionary, Financial, Encyclopedia.
Related to tachykinin: tachykinin 2, neurokinin 2

tach·y·ki·nin

(tak'i-kī'nin),
Any member of a group of polypeptides, widely scattered in vertebrate and invertebrate tissues, which have in common four of the five terminal amino acids: Phe-Xaa-Gly-Leu-Met-NH2; pharmacologically, they all cause hypotension in mammals, contraction of gut and bladder smooth muscle, and secretion of saliva.
[G. tachys, swift, + kineō, to move, + -in]
Farlex Partner Medical Dictionary © Farlex 2012

tachykinin

(tăk″kī′nĭn) [″ + ″],

TK

Any of a large family of peptides that function as neurotransmitters in the central and peripheral nervous systems. They have extraneuronal activity in other body tissues. Their diverse biological actions are mediated through cellular G proteins.
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Szallasi, "Comparison of tachykinin NK1 receptors in human IM9 and U373 MG cells, using antagonist (FK888, (+/-)-CP-96,345, and RP 67580) binding," European Journal of Pharmacology, vol.
Tachykinins are neuropeptides or proteins expressed throughout the nervous and immune systems, where they participate in many cellular and physiological processes and have been linked to multiple diseases, including chronic inflammation, cancer, infection and affective and addictive disorders.
Up-regulated genes included heparan sulfate proteoglycan 2 (HSPG2), hyaluronoglucosaminidase 1 (HYAL1) and interleukin 7 (IL-7), and down-regulated genes included interleukin 6 (1L-6), and C-reactive protein (CRP), as well as cathepsin G (CTSG), tachykinin receptor 1 (TACR1), chemokine (C-X3-C motif) ligand 1(CX3CL1), frizzled homolog 1 (FZD1), and insulin-like growth factor 2 (IGF2).
Maggi, "Tachykinins and tachykinin receptors: a growing family," Life Sciences, vol.
The ventral tegmental area as a putative target for tachykinins in cardiovascular regulation.
Participation of peripheral tachykinin NK1 receptors in the carrageenan-induced inflammation of the rat temporomandibular joint.
FA inhalation induces tachykinin release from sensory nerve endings in rats [51].
In another study patients with GER and chronic cough were shown to have 50-100 times more of the tachykinin substance P in their sputum when compared to GER patients without chronic cough or healthy subjects [16].
The Study of Conformational Equilibrium of [Glu-Trp-Gly-Leu-Met], a NK-2 Tachykinin Antagonist.
Under the definition of peptide hormones superfamily, they are defined as the intercellular messengers like adipokines (adiponectin, leptin, resistin), cytokines (chemokines, hematopoietic growth factors, hepatocyte growth factor, interferons, interleukines, lymphokines, monokines, osteopontin, transforming growth factor beta, TNF), endothelial growth factors, endothelins, fibroblast growth factor, quinines (bradykinin, kininogens, tachykinin) and platelet derived growth factor (see, http://www.ncbi.nlm.
Substance P is a mammalian tachykinin in the vagal afferent neurons that innervate the brainstem nucleus tractus solitarius, which sends impulses to the vomiting center.