Szallasi, "Comparison of tachykinin
NK1 receptors in human IM9 and U373 MG cells, using antagonist (FK888, (+/-)-CP-96,345, and RP 67580) binding," European Journal of Pharmacology, vol.
are neuropeptides or proteins expressed throughout the nervous and immune systems, where they participate in many cellular and physiological processes and have been linked to multiple diseases, including chronic inflammation, cancer, infection and affective and addictive disorders.
Up-regulated genes included heparan sulfate proteoglycan 2 (HSPG2), hyaluronoglucosaminidase 1 (HYAL1) and interleukin 7 (IL-7), and down-regulated genes included interleukin 6 (1L-6), and C-reactive protein (CRP), as well as cathepsin G (CTSG), tachykinin
receptor 1 (TACR1), chemokine (C-X3-C motif) ligand 1(CX3CL1), frizzled homolog 1 (FZD1), and insulin-like growth factor 2 (IGF2).
receptors: a growing family," Life Sciences, vol.
The ventral tegmental area as a putative target for tachykinins
in cardiovascular regulation.
Participation of peripheral tachykinin
NK1 receptors in the carrageenan-induced inflammation of the rat temporomandibular joint.
FA inhalation induces tachykinin
release from sensory nerve endings in rats .
In another study patients with GER and chronic cough were shown to have 50-100 times more of the tachykinin
substance P in their sputum when compared to GER patients without chronic cough or healthy subjects .
The Study of Conformational Equilibrium of [Glu-Trp-Gly-Leu-Met], a NK-2 Tachykinin
Under the definition of peptide hormones superfamily, they are defined as the intercellular messengers like adipokines (adiponectin, leptin, resistin), cytokines (chemokines, hematopoietic growth factors, hepatocyte growth factor, interferons, interleukines, lymphokines, monokines, osteopontin, transforming growth factor beta, TNF), endothelial growth factors, endothelins, fibroblast growth factor, quinines (bradykinin, kininogens, tachykinin
) and platelet derived growth factor (see, http://www.ncbi.nlm.
Substance P is a mammalian tachykinin
in the vagal afferent neurons that innervate the brainstem nucleus tractus solitarius, which sends impulses to the vomiting center.