synthetase

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synthetase

 [sin´thĕ-tās]
ligase; any of a class of enzymes that catalyze the joining together of two molecules coupled with the breakdown of a pyrophosphate bond in ATP or a similar triphosphate.

syn·the·tase

(sin'thĕ-tās),
An enzyme catalyzing the synthesis of a specific substance. Synthetase is limited, in the Enzyme Commission Report, to use as a trivial name for the ligases (EC class 6), which in turn are those synthesizing enzymes that require the cleavage of a pyrophosphate linkage in ATP or a similar compound. Reversal of lyase (EC class 4) reactions, producing a synthesis, is indicated (in trivial names) by synthase; such reactions do not involve pyrophosphate cleavage. For individual synthetases, see the specific names.

synthetase

/syn·the·tase/ (-thĕ-tās) a term used in the names of some of the ligases, no longer favored because of its similarity to synthase and its emphasis on reaction products.

synthetase

(sĭn′thĭ-tās′, -tāz′)
n.
Any of a group of enzymes that catalyze the synthesis of a compound. Also called synthase.

syn·the·tase

(sin'thĕ-tās)
An enzyme catalyzing the synthesis of a specific substance.

synthetase

ligase; any of a class of enzymes that catalyze the joining together of two molecules coupled with the breakdown of a pyrophosphate bond in ATP or a similar triphosphate.

aminoacyl-tRNA s's
see trna.
References in periodicals archive ?
Aminoacyl tRNA synthetases are associated with - and we believe needed for - the building of organismal complexity, such as making tissues and organs in humans," Paul Schimmel from the Scripps Research Institute in California explained in a (http://www.
Scientists believe further studies investigating the function of the reshaped C-Ala may shed light on diseases linked to mutations in aminoacyl tRNA synthetases.
Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration.
CAVALIER-SMITH: I didn't understand why, in your second scenario for the lysyl-tRNA synthetase, you suggested gene transfer rather than a change in the specificity of an amino-acyl tRNA synthetase.
It was reported earlier in this meeting that they also have this archael-type lysyl tRNA synthetase.
In the case of the lysyl tRNA synthetase (4) the spirochaetes have the archaeal type of enzyme, but Deinococcus does not.
I have carried out a site-by-site analysis for the amino acid tRNA synthetase and was struck by the fact that about half of the sites are highly variable, and about half of the sites could be considered more-or-less slowly evolving; even in that case, I found about ten sites in the tRNA synthetase that could be polarized (6).
An expert on tRNA synthetases, Paul Schimmel has also been the co-founder or founding director of numerous successful biotechnology companies, including Sirtris Pharmaceuticals, Alnylam, Repligen Corporation, Alkermes, Inc.
These genes include a) components of the RNAP II general transcription machinery (RPB8, RPB10, TAF10; Figure 5A); b) transcription termination and polyadenylation factors (NSAP1; Figure 5A); c) mRNA splicing factors (SFPQ, U2AF1, RNPS1; Figure 5A); d) mRNA export proteins (NXF1; Figure 5C); e) protein translation factors (EIF1A, EIF2A, EIF2B, EIF3; ribosomal proteins RPL11, RPL12, RPL20, RPL52, RPS18b, and tRNA synthetases VALRS, GLURS, PHERS; Figure 5D), and f) protein folding factors (FKBP4, CCT3, CCT6a, CCT7, CCT8; Figure 5E).
This brings up the question of dealing with substrates, tRNAs that are highly mutable; doesn't that make it much more difficult to discern the origins of things like tRNA synthetases by your hypothesis, than things like glyceraldehyde-3-phosphate dehydrogenase?
13) reached similar conclusions by a very different route, based on the modular interaction of tRNA synthetases with the top and bottom halves of tRNA.